3796-63-2

3796-63-2 structure

Name: (5E,9E,13E)-Teprenone
Chemical Name: Teprenone
CAS Number: 3796-63-2
Molecular Formula: C₂₃H₃₈O
Molecular Weight: 661.09400
Catalog: Organic raw materials Ketone compound
Create Date: 2016-12-23 18:32:56
Modify Date: 2024-01-10 07:57:49
(5E,9E,13E)-Teprenone ((5E,9E,13E)-Geranylgeranylacetone) is an isomer of Teprenone with antiulcer activity. (5E,9E,13E)-Teprenone induces transcriptional activation of HSP genes that may increase gastric mucosal defense at conditions of stress[1].

Name	Teprenone
Synonyms	6,10,14,18-tetramethyl-nonadeca-5t,9t,13t,17-tetraen-2-one E-0671 6,10,14,18-Tetramethyl-nonadeca-5t,9t,13t,17-tetraen-2-on (5E,9E,13E)-6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetren-2-one (5E,9E,13E)-6,10,14,18-tetramethyl-nonadeca-5,9,13,17-tetraen-2-one 5,9,13,17-Nonadecatetraen-2-one,6,10,14,18-tetramethyl-,(E,E,E) 2-Oxo-6,10,14,18-tetramethyl-nonadecatetraen-(5.9.13.17) (E,E,E)-geranylgeranylacetone E,E,E-geranylgeranylacetyl

Description	(5E,9E,13E)-Teprenone ((5E,9E,13E)-Geranylgeranylacetone) is an isomer of Teprenone with antiulcer activity. (5E,9E,13E)-Teprenone induces transcriptional activation of HSP genes that may increase gastric mucosal defense at conditions of stress[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	(5E,9E,13E)-Teprenone might transiently activate the transcription of HSP70 gene[1]. The heat shock element–binding activity reflects the activation of heat shock factor 1 in response to (5E,9E,13E)-Teprenone[1].
In Vivo	(5E,9E,13E)-Teprenone induces hat sock proteins accumulations in rat gastric mucosa[1]. Animal Model: Male Wister strain rats (≈250 g)[1] Dosage: 200 mg/kg Administration: Oral administration Result: Caused accumulations of all of HSP90, HSP70, HSC70 and HSP60 within 60 minutes.
References	[1]. Hirakawa T, et al. Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa. Gastroenterology. 1996 Aug;111(2):345-57.