1192750-33-6

1192750-33-6 structure

Name: PE 154
Chemical Name: 2-(4-(((7-(diethylamino)-2,4-dioxo-2H-chromen-3(4H)-ylidene)methyl)amino)phenyl)-N'-1,2,3,4-tetrahydroacridin-9-ylacetohydrazide
CAS Number: 1192750-33-6
Molecular Formula: C₃₅H₃₅N₅O₄
Molecular Weight: 589.68300
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2018-06-13 23:37:08
Modify Date: 2024-01-07 21:20:57
PE154 (Compound 13) is a potent fluorescent inhibitor of human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC50s=280 pM and 16 nM, respectively)[1]. PE154 can label β-amyloid plaques in histochemical analysis[2].

Name	2-(4-(((7-(diethylamino)-2,4-dioxo-2H-chromen-3(4H)-ylidene)methyl)amino)phenyl)-N'-1,2,3,4-tetrahydroacridin-9-ylacetohydrazide

Description	PE154 (Compound 13) is a potent fluorescent inhibitor of human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC50s=280 pM and 16 nM, respectively)[1]. PE154 can label β-amyloid plaques in histochemical analysis[2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	Butyrylcholinesterase:16 nM (IC50) Acetylcholinesterase:280 pM (IC50)
In Vivo	PE154 (hippocampus injection; 0.2 μg per mouse; once) can stain the histochemical of cortical βamyloid plaques[2]. Animal Model: 13–20-month-old triple-transgenic mice harbouring three mutant genes (APPswe, PS-1 and tauP301L)[2] Dosage: 0.2 μg per mouse Administration: Hippocampus injection; 0.2 μg per mouse; once Result: Showed the histochemical staining of cortical βamyloid plaques in triple-transgenic (TTG) mice.
References	[1]. Paul W Elsinghorst, et al. A gorge-spanning, high-affinity cholinesterase inhibitor to explore beta-amyloid plaques. Org Biomol Chem. 2009 Oct 7;7(19):3940-6. [2]. Davide Brambilla, et al. Nanotechnologies for Alzheimer's disease: diagnosis, therapy, and safety issues. Nanomedicine. 2011 Oct;7(5):521-40.

RIDADR	NONH for all modes of transport