Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Phox-I2
Price: Check
Purity: 99.52%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: Phox-I2
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

353495-22-4

353495-22-4 structure

353495-22-4 structure

Name: Phox-I2
Chemical Name: Phox-I2
CAS Number: 353495-22-4
Molecular Formula: C₁₈H₁₅N₃O₄
Molecular Weight: 337.33
Create Date: 2018-01-15 08:01:09
Modify Date: 2024-07-19 10:42:32
Phox-I2 is a selective inhibitor of p67phox-Rac1 interaction, binds to p67phox with high affinity with a Kd of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production[1].

Name	Phox-I2

Description	Phox-I2 is a selective inhibitor of p67phox-Rac1 interaction, binds to p67phox with high affinity with a Kd of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production[1].
Related Catalog	Research Areas >> Inflammation/Immunology
Target	Kd: 150 nM (p67phox)[1]
In Vitro	Phox-I2 可有效抑制 dHL-60 细胞和原代人中性粒细胞中 NOX2 介导的超氧化物产生，并具有剂量依赖性，且没有可检测到的细胞毒性[1]。
References	[1]. Emily E Bosco, et al. Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation. Chem Biol. 2012 Feb 24;19(2):228-42.

Molecular Formula	C₁₈H₁₅N₃O₄
Molecular Weight	337.33
Exact Mass	337.10600
PSA	103.67000
LogP	5.51390

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H335
Precautionary Statements	P261
RIDADR	NONH for all modes of transport

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