38376-29-3
38376-29-3 structure
- Name: VU0420373
- Chemical Name: 2-(3-(2-fluorophenyl)-1H-pyrazol-5-yl)phenol
- CAS Number: 38376-29-3
- Molecular Formula: C15H11FN2O
- Molecular Weight: 254.25900
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2018-03-17 11:46:45
- Modify Date: 2025-09-20 18:20:38
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VU0420373 is a potent heme sensor system (HssRS) activator with an EC50 of 10.7 μM and a pEC50 of 4.97. VU0420373 induces heme biosynthesis, and is toxic to fermenting S. aureus[1].
| Name | 2-(3-(2-fluorophenyl)-1H-pyrazol-5-yl)phenol |
|---|
| Description | VU0420373 is a potent heme sensor system (HssRS) activator with an EC50 of 10.7 μM and a pEC50 of 4.97. VU0420373 induces heme biosynthesis, and is toxic to fermenting S. aureus[1]. |
|---|---|
| Related Catalog | |
| Target |
EC50: 10.7 μM (HssRS)[1] pEC50: 4.97 (HssRS)[1] |
| In Vitro | VU0420373 (compound 2e) has an IC50 of >60 μM for Newman aerobic and Newman anaerobic, respectively[1]. VU0420373 (40 μM; 2, 4, 6, 8 hours) is able to preadapt S. aureus to a toxic concentration of heme (20 μM)[1]. |
| References |
| Molecular Formula | C15H11FN2O |
|---|---|
| Molecular Weight | 254.25900 |
| Exact Mass | 254.08600 |
| PSA | 48.91000 |
| LogP | 3.58840 |
