VU0420373
Modify Date: 2024-01-08 15:31:20
VU0420373 structure
|
Common Name | VU0420373 | ||
|---|---|---|---|---|
| CAS Number | 38376-29-3 | Molecular Weight | 254.25900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H11FN2O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of VU0420373VU0420373 is a potent heme sensor system (HssRS) activator with an EC50 of 10.7 μM and a pEC50 of 4.97. VU0420373 induces heme biosynthesis, and is toxic to fermenting S. aureus[1]. |
| Name | 2-(3-(2-fluorophenyl)-1H-pyrazol-5-yl)phenol |
|---|
| Description | VU0420373 is a potent heme sensor system (HssRS) activator with an EC50 of 10.7 μM and a pEC50 of 4.97. VU0420373 induces heme biosynthesis, and is toxic to fermenting S. aureus[1]. |
|---|---|
| Related Catalog | |
| Target |
EC50: 10.7 μM (HssRS)[1] pEC50: 4.97 (HssRS)[1] |
| In Vitro | VU0420373 (compound 2e) has an IC50 of >60 μM for Newman aerobic and Newman anaerobic, respectively[1]. VU0420373 (40 μM; 2, 4, 6, 8 hours) is able to preadapt S. aureus to a toxic concentration of heme (20 μM)[1]. |
| References |
| Molecular Formula | C15H11FN2O |
|---|---|
| Molecular Weight | 254.25900 |
| Exact Mass | 254.08600 |
| PSA | 48.91000 |
| LogP | 3.58840 |