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107355-45-3

107355-45-3 structure
107355-45-3 structure
  • Name: WIN 54954
  • Chemical Name: 5-{5-[2,6-dichloro-4-(4,5-dihydro-2-oxazolyl)phenoxy]pentyl}-3-methylisoxazole
  • CAS Number: 107355-45-3
  • Molecular Formula: C18H20Cl2N2O3
  • Molecular Weight: 383.27
  • Catalog: Research Areas Infection
  • Create Date: 2018-05-11 06:43:46
  • Modify Date: 2025-08-27 20:39:21
  • WIN 54954 is a broad-spectrum antipicornavirus agent. WIN 54954 is effectiveness against human rhinovirus, echovirus 9 and enterovirus infections[1][2].

Name 5-{5-[2,6-dichloro-4-(4,5-dihydro-2-oxazolyl)phenoxy]pentyl}-3-methylisoxazole
Synonyms 5-<5-(2,6-dichloro-5-oxazolylphenoxy)pentyl>-3-methylisoxazole
5-{5-[2,6-Dichloro-4-(4,5-dihydro-oxazol-2-yl)-phenoxy]-pentyl}-3-methyl-isoxazole
5-(5-(2,6-dichloro-4-(4,5-dihydro-2-oxazolyl)phenoxy)pentyl)-3-methylisoxazole
WIN 54954
Win 54954
5-{5-[2,6-Dichloro-4-(4,5-dihydro-2-oxazolyl)phenoxyl]-pentyl}-3-methylisoxazole
Description WIN 54954 is a broad-spectrum antipicornavirus agent. WIN 54954 is effectiveness against human rhinovirus, echovirus 9 and enterovirus infections[1][2].
Related Catalog
In Vitro WIN 54954 reduces plaque formation of 50 of 52 rhinovirus serotypes (MICs ranges from 0.007 to 2.2 μg/mL)[1].WIN 54954 inhibits 15 commonly isolated enteroviruses, with an EC80 of 0.06 μg/mL[1].
In Vivo WIN 54954 (2-100 mg/kg; p.o.) protects 50% of the mice from developing paralysis following infection with coxsackievirus A-9 and echovirus-9 at the dose of 2 and 100 mg/kg, respectively[1].
References

[1]. Woods MG, et, al. In vitro and in vivo activities of WIN 54954, a new broad-spectrum antipicornavirus drug. Antimicrob Agents Chemother. 1989 Dec;33(12):2069-74.

[2]. Fechner H, et, al. Pharmacological and biological antiviral therapeutics for cardiac coxsackievirus infections. Molecules. 2011 Oct 11;16(10):8475-503.

Molecular Formula C18H20Cl2N2O3
Molecular Weight 383.27
Exact Mass 382.08500
PSA 56.85000
LogP 4.29400
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