914638-30-5

914638-30-5 structure

Name: IDO-IN-1
Chemical Name: 4-Amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
CAS Number: 914638-30-5
Molecular Formula: C₉H₇BrFN₅O₂
Molecular Weight: 316.08700
Catalog: Signaling Pathways Metabolic Enzyme/Protease Indoleamine 2,3-Dioxygenase (IDO)
Create Date: 2018-12-05 12:29:13
Modify Date: 2024-01-14 15:42:02
IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 59 nM.

Name	4-Amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
Synonyms	IDO-IN-1 4-amino-N(3-bromo-4-fluorophenyl)-N-hydroxy-

Description	IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 59 nM.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO) Research Areas >> Cancer
Target	IDO:59 nM (IC50) IDO:12 nM (IC50, in HeLa cell)
In Vitro	IDO-IN-1 (Compound 5m) is a potent (HeLa IC50=12 nM) inhibitor of IDO[1].
References	[1]. Yue EW, et al. Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. J Med Chem. 2009 Dec 10;52(23):7364-7.