Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Heparastatin
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Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4,5-Dihydroxy-6-((trifluoroacetyl)amino)-3-piperidinecarboxylic acid ( 3S-(3alpha,4alpha,5alpha,6beta))-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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153758-25-9

153758-25-9 structure

153758-25-9 structure

Name: Heparastatin
Chemical Name: (3S,4S,5R,6R)-4,5-dihydroxy-6-(trifluoroacetamido)piperidine-3-carboxylic acid hydrochloride
CAS Number: 153758-25-9
Molecular Formula: C₈H₁₁F₃N₂O₅
Molecular Weight: 272.17900
Catalog: Research Areas Metabolic Disease
Create Date: 2018-06-05 20:06:07
Modify Date: 2024-01-10 16:44:13
Heparastatin is a heparanase inhibitor.

Name	(3S,4S,5R,6R)-4,5-dihydroxy-6-(trifluoroacetamido)piperidine-3-carboxylic acid hydrochloride
Synonyms	(3S,4S,5R,6R)-4,5-Dihydroxy-6-(2,2,2-trifluoro-acetylamino)-piperidine-3-carboxylic acid (3S,4S,5R,6R)-6-(trifluoroacetamido)-4,5-dihydroxy-3-piperidinecarboxylic acid (3S,4S,5R,6R)-6-(trifluoroacetamido)-4,5-dihydroxypiperidine-3-carboxylic acid

Description	Heparastatin is a heparanase inhibitor.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
Target	heparanase[1].
In Vitro	Addition of 100 μM of Heparastatin (SF4) completely inhibits the enzyme activity of heparanase at a concentration of 0.15 μg/mL in an in vitro degradation assay. Addition of Heparastatin during the transition process does not affect the phenotypic change of TGF-β-treated cells[2].
Cell Assay	Influence of a heparanase inhibitor on TGF-β3-induced EMT of NMuMG cells. NMuMG cells are cultured with 1 ng/mL TGF-β3 together with 10 or 100 μM Heparastatin (SF4) for 48 h[2].
References	[1]. Sue M, et al. An iminosugar-based heparanase inhibitor heparastatin (SF4) suppresses infiltration of neutrophils and monocytes into inflamed dorsal air pouches. Int Immunopharmacol. 2016 Jun;35:15-21. [2]. Yusuke Kogane, et al. Heparanase Downmodulation in the Process of Epithelial-to-Mesenchymal Transition of Mouse Mammary Epithelial Cells. Kogane et al., J Glycomics Lipidomics 2013, 3:1.

Molecular Formula	C₈H₁₁F₃N₂O₅
Molecular Weight	272.17900
Exact Mass	272.06200
PSA	118.89000

Hazard Codes	Xi

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