153758-25-9
153758-25-9 structure
- Name: Heparastatin
- Chemical Name: (3S,4S,5R,6R)-4,5-dihydroxy-6-(trifluoroacetamido)piperidine-3-carboxylic acid hydrochloride
- CAS Number: 153758-25-9
- Molecular Formula: C8H11F3N2O5
- Molecular Weight: 272.17900
- Catalog: Research Areas Metabolic Disease
- Create Date: 2018-06-05 20:06:07
- Modify Date: 2024-01-10 16:44:13
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Heparastatin is a heparanase inhibitor.
| Name | (3S,4S,5R,6R)-4,5-dihydroxy-6-(trifluoroacetamido)piperidine-3-carboxylic acid hydrochloride |
|---|---|
| Synonyms |
(3S,4S,5R,6R)-4,5-Dihydroxy-6-(2,2,2-trifluoro-acetylamino)-piperidine-3-carboxylic acid
(3S,4S,5R,6R)-6-(trifluoroacetamido)-4,5-dihydroxy-3-piperidinecarboxylic acid (3S,4S,5R,6R)-6-(trifluoroacetamido)-4,5-dihydroxypiperidine-3-carboxylic acid |
| Description | Heparastatin is a heparanase inhibitor. |
|---|---|
| Related Catalog | |
| Target |
heparanase[1]. |
| In Vitro | Addition of 100 μM of Heparastatin (SF4) completely inhibits the enzyme activity of heparanase at a concentration of 0.15 μg/mL in an in vitro degradation assay. Addition of Heparastatin during the transition process does not affect the phenotypic change of TGF-β-treated cells[2]. |
| Cell Assay | Influence of a heparanase inhibitor on TGF-β3-induced EMT of NMuMG cells. NMuMG cells are cultured with 1 ng/mL TGF-β3 together with 10 or 100 μM Heparastatin (SF4) for 48 h[2]. |
| References |
| Molecular Formula | C8H11F3N2O5 |
|---|---|
| Molecular Weight | 272.17900 |
| Exact Mass | 272.06200 |
| PSA | 118.89000 |
| Hazard Codes | Xi |
|---|