194413-58-6

194413-58-6 structure

Name: Semaxanib (SU5416)
Chemical Name: SeMaxanib
CAS Number: 194413-58-6
Molecular Formula: C₁₅H₁₄N₂O
Molecular Weight: 238.28400
Catalog: Biochemical Inhibitor Protein tyrosine kinase
Create Date: 2016-08-30 09:06:04
Modify Date: 2026-06-30 22:53:19
(Z)-Semaxanib (compound (z)-1) is a potent tyrosine kinase inhibitor. (Z)-Semaxanib shows cytotoxicity for TAMH and HepG2 cells with IC50s of 6.28 µM and 8.17 µM, respectively[1].

Name	SeMaxanib
Synonyms	TSU 16 3-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one Semaxanib (SU5416) TSU 16 Sematilide HCl SeMaxanib,SU5416 (Z)-Semaxinib 3-((2,4-DIMETHYLPYRROL-5-YL)METHYLIDENYL)-2-INDOLONONE 3-[(2,4-Dimethylpyrrol-5-yl)methylidenyl]-2-indolinon 2H-Indol-2-one, 3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-1,3-dihydro-, (Z) Semaxanib (Z)-SU Semaxanib 2H-Indol-2-one, 3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-1,3-dihydro-, (3Z) 3-(1-(3,5-Dimethyl-1H-pyrrol-2-yl)meth-(Z)-ylidene)-2-oxo-2,3-dihydroindole (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1H-indol-2-one (3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one (Z) Semaxinib,(Z)-Semaxanib,(Z)-SU5416,TAMH cells,c-Met/HGFR,(Z)Semaxinib,inhibit,Inhibitor,HG2 cells,cytotoxicity CK 1752A Unii-71ia9S35aj (Z)-SU 3-((Z)-(3,5-Dimethylpyrrol-2-yl)methylene)-2-indolinone SEMATILIDE HYDROCHLORIDE 3-[(2,4-Dimethylpyrrol-5-yl)methylidenyl]-2-indolinon //BP Sematilide monohydrochloride 17022(Z) (Z)-Semaxinib, 10 mM in DMSO

Description	(Z)-Semaxanib (compound (z)-1) is a potent tyrosine kinase inhibitor. (Z)-Semaxanib shows cytotoxicity for TAMH and HepG2 cells with IC50s of 6.28 µM and 8.17 µM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR
References	[1]. Ngai MH, So CL, Sullivan MB, Ho HK, Chai CL. Photoinduced Isomerization and Hepatoxicities of Semaxanib, Sunitinib and Related 3-Substituted Indolin-2-ones. ChemMedChem. 2016 Jan 5;11(1):72-80.

2199-58-8

59-48-3

~79%

194413-58-6

2199-58-8

152302-94-8

~65%

194413-58-6

Literature: Lubkoll, Jana; Millemaggi, Alessia; Perry, Alexis; Taylor, Richard J.K. Tetrahedron, 2010 , vol. 66, # 33 p. 6606 - 6612

110-89-4

2199-58-8

59-48-3

~57%

194413-58-6

Literature: Sugen, Inc. Patent: US6846839 B1, 2005 ;

2199-58-8

1243657-66-0

~19%

194413-58-6

Literature: Lubkoll, Jana; Millemaggi, Alessia; Perry, Alexis; Taylor, Richard J.K. Tetrahedron, 2010 , vol. 66, # 33 p. 6606 - 6612

Precursor 4
2199-58-8 59-48-3 152302-94-8 110-89-4
DownStream 0