194413-58-6

194413-58-6 structure

Name: Semaxanib (SU5416)
Chemical Name: SeMaxanib
CAS Number: 194413-58-6
Molecular Formula: C₁₅H₁₄N₂O
Molecular Weight: 238.28400
Catalog: Biochemical Inhibitor Protein tyrosine kinase
Create Date: 2016-08-30 09:06:04
Modify Date: 2025-08-22 13:40:28
(Z)-Semaxanib (compound (z)-1) is a potent tyrosine kinase inhibitor. (Z)-Semaxanib shows cytotoxicity for TAMH and HepG2 cells with IC50s of 6.28 µM and 8.17 µM, respectively[1].

Name	SeMaxanib
Synonyms	CK 1752A Sematilide HCl Sematilide monohydrochloride SEMATILIDE HYDROCHLORIDE Semaxanib (SU5416)

Description	(Z)-Semaxanib (compound (z)-1) is a potent tyrosine kinase inhibitor. (Z)-Semaxanib shows cytotoxicity for TAMH and HepG2 cells with IC50s of 6.28 µM and 8.17 µM, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR
References	[1]. Ngai MH, So CL, Sullivan MB, Ho HK, Chai CL. Photoinduced Isomerization and Hepatoxicities of Semaxanib, Sunitinib and Related 3-Substituted Indolin-2-ones. ChemMedChem. 2016 Jan 5;11(1):72-80.

2199-58-8

59-48-3

~79%

194413-58-6

2199-58-8

152302-94-8

~65%

194413-58-6

Literature: Lubkoll, Jana; Millemaggi, Alessia; Perry, Alexis; Taylor, Richard J.K. Tetrahedron, 2010 , vol. 66, # 33 p. 6606 - 6612

110-89-4

2199-58-8

59-48-3

~57%

194413-58-6

Literature: Sugen, Inc. Patent: US6846839 B1, 2005 ;

2199-58-8

1243657-66-0

~19%

194413-58-6

Literature: Lubkoll, Jana; Millemaggi, Alessia; Perry, Alexis; Taylor, Richard J.K. Tetrahedron, 2010 , vol. 66, # 33 p. 6606 - 6612

Precursor 4
2199-58-8 59-48-3 152302-94-8 110-89-4
DownStream 0