1177600-74-6

1177600-74-6 structure

Name: SMANT hydrochloride
Chemical Name: N-(4-Bromophenyl)-3-(3,5-dimethyl-1-piperidinyl)propanamide hydro chloride (1:1)
CAS Number: 1177600-74-6
Molecular Formula: C₁₆H₂₄BrClN₂O
Molecular Weight: 375.73200
Catalog: Signaling Pathways Stem Cell/Wnt Hedgehog
Create Date: 2016-06-02 19:12:59
Modify Date: 2024-01-29 13:48:57
SMANT hydrochloride is a Smoothened (Smo) signaling inhibitor. SMANT hydrochloride is antagonist of Smo accumulation within the primary cilium (PC). SMANT hydrochloride has an equivalent activity in inhibiting SmoM2 (oncogenic form of Smo) and wild-type Smo[1].

Name	N-(4-Bromophenyl)-3-(3,5-dimethyl-1-piperidinyl)propanamide hydro chloride (1:1)

Description	SMANT hydrochloride is a Smoothened (Smo) signaling inhibitor. SMANT hydrochloride is antagonist of Smo accumulation within the primary cilium (PC). SMANT hydrochloride has an equivalent activity in inhibiting SmoM2 (oncogenic form of Smo) and wild-type Smo[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Smo Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> Hedgehog
Target	Smo, SmoM2[1]
In Vitro	SMANT (0-10 μM, NIH/3T3 cells) hydrochloride inhibits Hh induced Smo accumulation at the primary cilium (IC50: 1.1 μM)[1]. SMANT (0-10 μM, NIH/3T3 cells) hydrochloride inhibits Smo and SmoM2 activity, and blocks the stimulatory action of SAG in Gli-luciferase assay[1]. SMANT (0-10 μM) hydrochloride inhibits proliferation of cerebellar granule-cell neural progenitors (CGNP) (isolated from Ptch1+/− neonates) induced by Shh[1].
References	[1]. Wang Y, et al. Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation. ACS Chem Biol. 2012 Jun 15;7(6):1040-8.