14142-64-4
14142-64-4 structure
- Name: Cletoquine oxalate
- Chemical Name: 2-[4-[(7-chloroquinolin-4-yl)amino]pentylamino]ethanol,oxalic acid
- CAS Number: 14142-64-4
- Molecular Formula: C18H24ClN3O5
- Molecular Weight: 397.85300
- Catalog: Signaling Pathways Anti-infection Influenza Virus
- Create Date: 2018-06-11 09:13:58
- Modify Date: 2025-08-26 20:17:07
-
Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment[1][2].
| Name | 2-[4-[(7-chloroquinolin-4-yl)amino]pentylamino]ethanol,oxalic acid |
|---|---|
| Synonyms | Cletoquine Oxalate |
| Description | Cletoquine oxalate (Desethylhydroxychloroquine oxalate) is a major active metabolite of Hydroxychloroquine. Cletoquine oxalate is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine oxalate is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine oxalate has antimalarial effects and has the potential for autoimmune diseases treatment[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Chikungunya virus (CHIKV)[2] |
| In Vivo | Hydroxychloroquine (5 mg/kg intravenously) is administered to BALB/c mice for blood and tissue to determine the content of Cletoquine (Desethylhydroxychloroquine). The tissue to blood concentration ratio (Kp) is ≥1, indicating accumulation of Cletoquine in tissues. The Cletoquine Kp ratio for the various tissues are observed in the descending order of liver (114.3)>kidney (24.4)>spleen (19.3)>lungs (16.5)>heart (5.5)[3]. |
| References |
| Molecular Formula | C18H24ClN3O5 |
|---|---|
| Molecular Weight | 397.85300 |
| Exact Mass | 397.14000 |
| PSA | 131.78000 |
| LogP | 2.67020 |