1206101-20-3

1206101-20-3 structure

Name: GLPG0634
Chemical Name: N-(5-{4-[(6-Cyano-3-pyridinyl)methoxy]phenyl}[1,2,4]triazolo[1,5- a]pyridin-2-yl)cyclopropanecarboxamide
CAS Number: 1206101-20-3
Molecular Formula: C₂₃H₁₈N₆O₂
Molecular Weight: 410.428
Catalog: Biochemical Inhibitor Tyrosine protein kinase/signal transducer and transcriptional activator inhibitor (JAK/STAT) JAK inhibitor
Create Date: 2018-12-22 16:59:49
Modify Date: 2024-01-02 16:01:59
GLPG0634 (analog) (compound176)is a pan JAK inhibitor with IC50s of 50-200 nM for JAK1/JAK2/JAK3; more information can be found in the reference patents.

Name	N-(5-{4-[(6-Cyano-3-pyridinyl)methoxy]phenyl}[1,2,4]triazolo[1,5- a]pyridin-2-yl)cyclopropanecarboxamide
Synonyms	N-(5-{4-[(6-Cyano-3-pyridinyl)methoxy]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide Cyclopropanecarboxamide, N-[5-[4-[(6-cyano-3-pyridinyl)methoxy]phenyl][1,2,4]triazolo[1,5-a]pyridin-2-yl]- GLPG0634 GLPG0634 analogue GLPG0634 analog

Description	GLPG0634 (analog) (compound176)is a pan JAK inhibitor with IC50s of 50-200 nM for JAK1/JAK2/JAK3; more information can be found in the reference patents.
Related Catalog	Research Areas >> Cancer
Target	JAK3:<100 nM (IC50) Tyk2:<100 nM (IC50)
References	[1]. http://www.google.com/patents/WO2013173506A2cl=en [2]. http://www.google.it/patents/WO2010149769A1cl=en [3]. http://www.google.com/patents/WO2010010190A1cl=en

Hazard Codes	Xi

1142943-96-1

1206101-28-1

1206101-20-3

Literature: Menet, Christel Jeanne Marie; Blanc, Javier Patent: US2010/29709 A1, 2010 ; Location in patent: Page/Page column 26 ;

Precursor 1
1206101-28-1
DownStream 0