1110766-97-6

1110766-97-6 structure

Name: Lusutrombopag
Chemical Name: Lusutrombopag
CAS Number: 1110766-97-6
Molecular Formula: C₂₉H₃₂Cl₂N₂O₅S
Molecular Weight: 591.546
Catalog: Signaling Pathways Immunology/Inflammation Thrombopoietin Receptor
Create Date: 2018-08-19 15:12:14
Modify Date: 2024-01-02 15:05:09
Lusutrombopag is an orally bioavailable thrombopoietin (TPO) receptor agonist, used for treatment of chronic liver disease.

Name	Lusutrombopag
Synonyms	S-888711 Acide (2E)-3-{2,6-dichloro-4-[(4-{3-[(1S)-1-(hexyloxy)éthyl]-2-méthoxyphényl}-1,3-thiazol-2-yl)carbamoyl]phényl}-2-méthylacrylique (2E)-3-{2,6-Dichloro-4-[(4-{3-[(1S)-1-(hexyloxy)ethyl]-2-methoxyphenyl}-1,3-thiazol-2-yl)carbamoyl]phenyl}-2-methylacrylic acid 2-Propenoic acid, 3-[2,6-dichloro-4-[[[4-[3-[(1S)-1-(hexyloxy)ethyl]-2-methoxyphenyl]-2-thiazolyl]amino]carbonyl]phenyl]-2-methyl-, (2E)- (2E)-3-{2,6-Dichlor-4-[(4-{3-[(1S)-1-(hexyloxy)ethyl]-2-methoxyphenyl}-1,3-thiazol-2-yl)carbamoyl]phenyl}-2-methylacrylsäure

Description	Lusutrombopag is an orally bioavailable thrombopoietin (TPO) receptor agonist, used for treatment of chronic liver disease.
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Thrombopoietin Receptor Research Areas >> Inflammation/Immunology
In Vitro	Lusutrombopag acts selectively on the human TPO receptor and activates signal transduction pathways that promote the proliferation and differentiation of bone marrow cells into megakaryocytes, thereby increasing platelet levels[1].
References	[1]. Kim ES, et al. Lusutrombopag: First Global Approval. Drugs. 2016 Jan;76(1):155-8.