852057-94-4

852057-94-4 structure

Name: KMG-104
Chemical Name: kmg-104
CAS Number: 852057-94-4
Molecular Formula: C₂₃H₁₁F₂NO₆
Molecular Weight: 435.33
Catalog: Research Areas Neurological Disease
Create Date: 2018-04-08 08:30:21
Modify Date: 2024-01-08 00:18:49
KMG-104 is a highly selective fluorescent Mg2+ probe. KMG-104 has been used widely and revealed Mg2+ mobilization in cytoplasm in various types of cells[1].

Name	kmg-104
Synonyms	1-(2,7-Difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)-4-oxo-4H-quinolizine-3-carboxylic acid 1-(2,7-difluoro-6-hydroxy-3-oxo-3H-xanthen-9-yl)-4-oxo-4H-quinolizine-3-carboxylic acid

Description	KMG-104 is a highly selective fluorescent Mg2+ probe. KMG-104 has been used widely and revealed Mg2+ mobilization in cytoplasm in various types of cells[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	KMG-104 is useful for confocal laser scanning microscopy because it is excited at 490 nm, and emitted fluorescence around 510 nm. Fluorescent intensity of KMG-104 increases with [Mg] increase, and it shows no response to Na, K, and Ca; the dissociation constant (Kd) for Mg is 3 mM. KMG-104 is able to trace only [Mg] change inphysiological conditions[2]. PC12 cells are loaded with a novel Mg indicator KMG-104 and Ca indicator fura-2, and intracellular Mg is studied in the endoplasmic reticulums (ERs), mitochondria, and Mg-ATP[2].
References	[1]. Kubota T, et al. Investigation of intracellular magnesium mobilization pathways I PC12 cells B simultaneous Mg-Ca fluorescent imaging. J Am Coll Nutr. 2004;23(6):742S-4S. [2]. Fujii T, et al. Design and synthesis of a FlAsH-type Mg2+ fluorescent probe for specific protein labeling. J Am Chem Soc. 2014;136(6):2374-2381.