178606-66-1
178606-66-1 structure
- Name: U-104
- Chemical Name: 4-{[(4'-fluorophenyl)carbamoyl]amino}benzenesulfonamide
- CAS Number: 178606-66-1
- Molecular Formula: C13H12FN3O3S
- Molecular Weight: 309.316
- Catalog: Biochemical Inhibitor Metabolism Carbonic Anhydrase Inhibitor
- Create Date: 2018-12-15 12:42:29
- Modify Date: 2024-01-04 21:08:48
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U-104 is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki of 45.1 nM and 4.5 nM; low inhibition for CA I and CA II.IC50 value: 45.1 nM/4.5 nM(Ki, CA IX/CA XII) [1]Target: Carbonic anhydrase inhibitorin vitro: U-104 (50 μM) blocks the mesenchymal phenotype in the cancer stem cells population in hypoxia condition of 4T1 cells. U-104 (<50 μM) significantly reduces migration in a dose-dependent manner in metastatic MDA-MB-231 LM2-4Luc+ cells , with cells growing as compact colonies similar to parental MDA-MB-231 cells [2]. in vivo: U-104 (38 mg/kg) inhibits primary tumor growth in the mice implanted orthotopically with MDA-MB-231 LM2-4Luc+ cells. U-104 (19 mg/kg) inhibits metastases formation in the 4T1 experimental metastasis mice model [1]. U-104 (38 mg/kg) significantly delay primary tumor growth and reduces cancer stem cell population in NOD/SCID mice orthotopically implanted with MDA-MB-231 LM2-4Luc+ cells. U-104 (5 mg/mL, oral gavage) shows a significant delay in tumor growth in Balb/c mice orthotopically implanted with 4T1 cells [2].
| Name | 4-{[(4'-fluorophenyl)carbamoyl]amino}benzenesulfonamide |
|---|---|
| Synonyms |
Benzenesulfonamide, 4-[[[(4-fluorophenyl)amino]carbonyl]amino]-
Benzenesulfonamide (4-[[[(4-fluorophenyl)amino]carbonyl]amino] 4-{[(4-Fluorophenyl)carbamoyl]amino}benzenesulfonamide 4-[[[(4-Fluorophenyl)amino]carbonyl]amino]-benzenesulfonamide Carbonic Anhydrase IX/XII Inhibitor II(U-104) U-104 |
| Description | U-104 is a potent carbonic anhydrase (CA) inhibitor for CA IX and CA XII with Ki of 45.1 nM and 4.5 nM; low inhibition for CA I and CA II.IC50 value: 45.1 nM/4.5 nM(Ki, CA IX/CA XII) [1]Target: Carbonic anhydrase inhibitorin vitro: U-104 (50 μM) blocks the mesenchymal phenotype in the cancer stem cells population in hypoxia condition of 4T1 cells. U-104 (<50 μM) significantly reduces migration in a dose-dependent manner in metastatic MDA-MB-231 LM2-4Luc+ cells , with cells growing as compact colonies similar to parental MDA-MB-231 cells [2]. in vivo: U-104 (38 mg/kg) inhibits primary tumor growth in the mice implanted orthotopically with MDA-MB-231 LM2-4Luc+ cells. U-104 (19 mg/kg) inhibits metastases formation in the 4T1 experimental metastasis mice model [1]. U-104 (38 mg/kg) significantly delay primary tumor growth and reduces cancer stem cell population in NOD/SCID mice orthotopically implanted with MDA-MB-231 LM2-4Luc+ cells. U-104 (5 mg/mL, oral gavage) shows a significant delay in tumor growth in Balb/c mice orthotopically implanted with 4T1 cells [2]. |
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| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Melting Point | 242-243℃ |
| Molecular Formula | C13H12FN3O3S |
| Molecular Weight | 309.316 |
| Exact Mass | 309.058350 |
| PSA | 109.67000 |
| LogP | 2.12 |
| Appearance | white to beige |
| Index of Refraction | 1.673 |
| Storage condition | 2-8°C |
| Water Solubility | DMSO: >15mg/mL |