1421502-62-6

1421502-62-6 structure

Name: PF-06263276
Chemical Name: PF-06263276
CAS Number: 1421502-62-6
Molecular Formula: C₃₁H₃₁FN₈O₂
Molecular Weight: 566.638
Catalog: Signaling Pathways Epigenetics JAK
Create Date: 2018-06-17 18:39:38
Modify Date: 2024-01-10 12:45:27
PF-06263276 (PF 6263276) is a potent and selective pan-JAK inhibitor, with IC50s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1, JAK2, JAK3 and TYK2, respectively[1].

Name	PF-06263276

Description	PF-06263276 (PF 6263276) is a potent and selective pan-JAK inhibitor, with IC50s of 2.2 nM, 23.1 nM, 59.9 nM and 29.7 nM for JAK1, JAK2, JAK3 and TYK2, respectively[1].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
Target	JAK1:2.2 nM (IC50) JAK2:23.1 nM (IC50) JAK3:59.9 nM (IC50) Tyk2:29.7 nM (IC50)
References	[1]. Jones P, et al. Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin. J Med Chem. 2017 Jan 26;60(2):767-786.