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83930-34-1

83930-34-1 structure
83930-34-1 structure
  • Name: [Tyr0] Corticotropin Releasing Factor, ovine
  • Chemical Name: Tyr-CRF (ovine)
  • CAS Number: 83930-34-1
  • Molecular Formula: C214H348N60O65S1
  • Molecular Weight: 4833.48
  • Catalog: Research Areas Endocrinology
  • Create Date: 2018-04-05 02:42:17
  • Modify Date: 2025-08-20 19:39:44
  • [Tyr0] Corticotropin Releasing Factor, ovine is a corticotropin releasing factor/hormone isolated from ovine. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin[1][2].
Name Tyr-CRF (ovine)
Synonyms H-Tyr-Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH2
Description [Tyr0] Corticotropin Releasing Factor, ovine is a corticotropin releasing factor/hormone isolated from ovine. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin[1][2].
Related Catalog
In Vitro [Tyr0] Corticotropin Releasing Factor, ovine has a strong binding effect with plasma protein[1].
In Vivo [Tyr0] Corticotropin Releasing Factor, ovine (328 μCi/μg; 198 pg/min or 225 pg/min; continuous infusions intravenous; single dose lasting 5-7 hr) shows a long plasma half-life and low metabolic clearance rate in male cynomolgus monkeys[1]. Animal Model: Young adult male cynomolgus monkeys (4.0-6.9 kg)[1] Dosage: 10 mL/h for 198 pg/min or 225 pg/min Administration: Continuous infusions intravenous; collected every 60 min during 5-7 hr Result: Showed a longer plasma half-life than for all other known hypothalamic peptides and its metabolic clearance rate was relatively low and considerably less all other known hypothalamic peptides or adreno-cortico-tropic-hormone (ACTH).
References

[1]. Schulte HM, et al. Metabolic clearance rate and plasma half-life of radioiodinated corticotropin releasing factor in a primate. J Clin Endocrinol Metab. 1982 Nov;55(5):1023-5.

[2]. Rebaudo R, et al. Electrophysiological effects of sustained delivery of CRF and its receptor agonists in hippocampal slices. Brain Res. 2001 Dec 13;922(1):112-7.

Molecular Formula C214H348N60O65S1
Molecular Weight 4833.48
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