1644545-52-7

1644545-52-7 structure

Name: Vorasidenib (AG-881)
Chemical Name: AG881
CAS Number: 1644545-52-7
Molecular Formula: C₁₄H₁₃ClF₆N₆
Molecular Weight: 414.74
Catalog: Signaling Pathways Metabolic Enzyme/Protease Isocitrate Dehydrogenase (IDH)
Create Date: 2018-05-21 08:00:00
Modify Date: 2024-01-08 12:05:04
Vorasidenib is a pan isocitrate dehydrogenase (IDH) inhibitor.

Name	AG881
Synonyms	Vorasidenib

Description	Vorasidenib is a pan isocitrate dehydrogenase (IDH) inhibitor.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Isocitrate Dehydrogenase (IDH) Research Areas >> Cancer
Target	IDH[1]
In Vitro	Vorasidenib has recently entered phase 1 clinical trials in hematologic (NCT02492737) and solid malignancies (NCT02481154) in patients with either an IDH1 or an IDH2 mutation. Preclinical studies have suggested that Vorasidenib fully penetrates the blood-brain barrier and may be a more effective option for patients with IDH1/2 mutated glioma[1].
References	[1]. Fujii T, et al. Targeting isocitrate dehydrogenase (IDH) in cancer. Discov Med. 2016 May;21(117):373-80.