1644545-52-7

• 常用中文名：Vorasidenib
• 常用英文名：Vorasidenib (AG-881)
• CAS号：1644545-52-7
• 分子式：C₁₄H₁₃ClF₆N₆
• 分子量：414.74
• 相关类别： 信号通路 代谢酶/蛋白酶 异柠檬酸脱氢酶(IDH)
• 发布时间：2018-05-21 08:00:00
• 更新时间：2026-08-06 12:48:04
• Vorasidenib 是一个非特异的异柠檬酸脱氢酶 (IDH) 抑制剂。

名称

• 中文名: Vorasidenib
• 英文名: AG881
• 中文别名: 氨基羧基磁珠; 3.5-二甲基苯酚; 乙醇杂质溶液A(标准品); 赛默飞D34679抗体试剂; 多功能钢铁表面处理浓缩液; LIX54-100萃取剂; IDH抑制剂(VORASIDENIB); PVM/MA共聚物,10 MM DMSO 溶液; 新型冠状病毒(SS-CoV-2)中和抗体ELISA检测试剂盒; 凡士; 2.2-二氟乙醇成品; 甲醇中4种氯酚类混标; 定制27种有机磷混标,2000 μg/mL溶于的二氯甲烷和丙酮; 6-(6-氯吡啶-2-基)-N2,N4-双((R)-1,1,1-三氟丙烷-2-基)-1,3,5-三嗪-2,4-二胺; 沃拉西德尼; 氯化纳 生理盐水; 人瓜氨酸组蛋白 H3(CITH3)试剂盒(ELISA); 人血栓调节蛋白(TM)试剂盒(ELISA); 23种芳香胺(偶氮)标准品,300ppm 溶于乙腈:甲醇=__PROTECTED__80:20; 8种氯苯+26种有机氯混标,100 μg/mL溶于正己烷丙酮; 2-(1-乙氧基乙烯基)-4,4,5,5-四乙基-1,3,2-二氧杂硼烷; 清洗剂AB-2; 仪器校准标准品2; VORASIDENIB (AG-881),抑制剂; (S)-1-氨基-1-(5-溴-2-氟苯基)乙烷-1-醇; 四甲基乙二,电泳,生物技术; 百菌清与溴氰菊酯混标,1000 μg/mL溶于甲醇; 4-(2-乙酰基-5-氯苯基)-5-甲氧基吡啶-2(1H)-酮; 无硫加臭剂; 人髓过氧化物酶-DNA 复合物(MPO-DNA)试剂盒(ELISA); 人纤溶酶抗纤溶酶复合物(PAP)试剂盒(ELISA)
• 英文别名: N,N-dimethyl-N-(oxiran-2-ylmethyl)octadecan-1-aminium chloride; 4-(2-acetyl-5-chlorophenyl)-5-methoxypyridin-2(1H)-one; FF10101; UK2001607; Trichloroethyl 2-(Bromomethyl)-2-hydroxyhehahydrofuro(3,2-b)pyridine-4(2H)-cboxylate; 2‐{2‐[2‐(2,2‐difluoroethoxy)ethoxy]ethoxy}‐1,1‐difluoroethane; TLC Plates,Silca Gel 60 F254 Aluminium Plating; PCB138; CALCIUM(C10-C16)ALKYLBENZENESULPHONATE; (5Z,8Z,11Z,14Z)-15-Hydroperoxyicosa-5,8,11,14-tetraenoic acid; Vorasidenib (AG881); 2,2'-(propane-2,2- diylbis(sulfanediyl))bis(ethan-1-ol); HS-01; 4-Cyano-1-(perfluoroethoxy)pyridin-1-ium bis((trifluoromethyl)sulfonyl)amide; 6-(6-chloropyridin-2-yl)-N2,N4-bis((R)-1,1,1-trifluoropropan-2-yl)-1,3,5-triazine-2,4-diamine; 4-hydrazineylnicotinamide; 15-HPETE; E-7386; SRD5A1-IN-1; s-22611; high quality 3-aminophenylacetylene HCL; N-Trifluoromethyltriazolyl-4-cboxamide; 2-(1-ethoxyvinyl)-4,4,5,5-tetraethyl-1,3,2-dioxaborolane; N-Difluoromethyltriazolyl-4-cboxamide; Sodium 2,3,3,3-Tetrafluoro-2-(1,1,2,2,2-Pentafluoroethoxy)propanoate; 1,3,5-Triazine-2,4-diamine, 6-(6-chloro-2-pyridinyl)-N2,N4-bis[(1R)-2,2,2-trifluoro-1-methylethyl]; FM381 FM-381; 15-HYDROPEROXYEICOSATETRAENOICACID; FF-10101; Amino Cboxyl Magnetic Beads; Sodium 2-azido-2,2-difluoroacetate; Vorasidenib; IMB-XH1; inhibit,AG 881,Vorasidenib,AG881,Inhibitor,Isocitrate Dehydrogenase (IDH); S-N-NITROSO-2-METHYLPIPERIDINE; (E)-Ethyl Docos-2-Enoate; 2-chloro-N1,N4-bis(4-cyanophenyl)terhthalamide; AG-881; AG 881; AG-881; (S)-1-amino-1-(5-bromo-2-fluorophenyl)ethan-1-ol; 4-N-(2,4-dimethoxyphenyl)-6-N-(4-(4-methylpiperazin-1-yl)phenyl)pyrimidine-4,6-diamine, N4-(2,4-dimethoxyphenyl)-N6-(4-(4-methylpiperazin-1-yl)phenyl)pyrimidine-4,6-diamine; 2-[1-(2-Hydroxy-ethylsulfanyl)-1-methyl-ethylsulfanyl]-ethanol; benzyl ester of L-cnitine; (+)-Quassin; 2-[3-(2H-indazol-3-ylmethyl)-2,4-dioxo-5-phenyl-1,5-benzodiazin-1-yl]-N-(4-methoxyphenyl)-N-propan-2-ylacetamide; 1-Difluoroethyltriazolyl-4-methylamine hydrochloride; AG081; (1-(2,2,3,3-Tetrafluoropropyl)-1H-1,2,3-triazol-4-yl)methanaminium chloride; PF06291874; FLEABUSTERSRXPOWDER; E7386; 3-bromo-5-bromoacetyl salicylamide; AKR1C3-IN-9; (5Z,8Z,11Z,14Z)-15-Hydroperoxy-5,8,11,14-icosatetraenoic acid; (R)-1-(3-(3-amino-6-(2-fluoro-5-isopropoxyphenyl)pyrazine-2-cboxamido)pyridin-4-yl)piperidine-3-cboxylic acid; PVM/MA

物化性质

• 分子式: C₁₄H₁₃ClF₆N₆
• 分子量: 414.74
• 外观性状: 粉末
• 储存条件: -20℃

生物活性

• 描述: Vorasidenib 是一个非特异的异柠檬酸脱氢酶 (IDH) 抑制剂。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 异柠檬酸脱氢酶(IDH)
  研究领域 >> 癌症
• 靶点:

  IDH[1]

• 体外研究: Vorasidenib最近在患有IDH1或IDH2突变的患者中进入了血液学(NCT02492737)和实体恶性肿瘤(NCT02481154)的1期临床试验。临床前研究表明,Vorasidenib完全穿透血脑屏障,对于IDH1/2突变性胶质瘤患者可能是更有效的选择[1]。
• 参考文献:

  [1]. Fujii T, et al. Targeting isocitrate dehydrogenase (IDH) in cancer. Discov Med. 2016 May;21(117):373-80.