108524-93-2

108524-93-2 structure

Name: Ilexsaponin A
Chemical Name: Ilexsaponin A
CAS Number: 108524-93-2
Molecular Formula: C₃₆H₅₆O₁₁
Molecular Weight: 664.823
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-07-18 14:34:11
Modify Date: 2024-01-04 16:23:21
Ilexsaponin A, isolated from the root of Ilex pubescens, attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. Ilexsaponin A can reduce myocardial infarct size, lower the serum levels of LDH, AST and CK-MB, increase cellular viability and inhibit apoptosis in hypoxia/reoxygenation cardiomyocytes[1].

Name	Ilexsaponin A
Synonyms	1-O-[(3β,5ξ)-3,19,23-Trihydroxy-23,28-dioxours-12-en-28-yl]-β-D-glucopyranose β-D-Glucopyranose, 1-O-[(3β,5ξ)-3,19,23-trihydroxy-23,28-dioxours-12-en-28-yl]- Ilexsaponin A1

Description	Ilexsaponin A, isolated from the root of Ilex pubescens, attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. Ilexsaponin A can reduce myocardial infarct size, lower the serum levels of LDH, AST and CK-MB, increase cellular viability and inhibit apoptosis in hypoxia/reoxygenation cardiomyocytes[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis
In Vitro	Ilexsaponin A significantly reduces proapoptotic proteins including caspase-3, cleaved caspase-3 and bax and increases anti-apoptotic protein bcl-2 in hypoxia/reoxygenation cardiomyocytes. Ilexsaponin A treatment increases the expression levels of p-Akt in hypoxia/reoxygenation cellular model and myocardial ischemia/reperfusion animal model[1].
In Vivo	Ilexsaponin A (10 or 40 mg/kg) reduce the myocardial infarct size in a dose dependent manner in male Sprague-Dawley rats weighing 280-320 g[1].
References	[1]. Zhang SW, et al. Ilexsaponin A attenuates ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway. PLoS One. 2017 Feb 9;12(2):e0170984.