402713-81-9
402713-81-9 structure
- Name: SB 399885 hydrochloride
- Chemical Name: SB-399885 hydrochloride
- CAS Number: 402713-81-9
- Molecular Formula: C18H22Cl3N3O4S
- Molecular Weight: 482.809
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2018-04-27 20:46:35
- Modify Date: 2024-01-08 12:51:49
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SB-399885 hydrochloride is a 5-HT6 receptor antagonist.
| Name | SB-399885 hydrochloride |
|---|---|
| Synonyms |
N-(3,5-Dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)benzenesulfonamide hydrochloride (1:1)
Benzenesulfonamide, N-(3,5-dichloro-2-methoxyphenyl)-4-methoxy-3-(1-piperazinyl)-, hydrochloride (1:1) |
| Description | SB-399885 hydrochloride is a 5-HT6 receptor antagonist. |
|---|---|
| Related Catalog | |
| Target |
5-HT6 receptor[1] |
| In Vivo | Compare with the control vehicle SB-399885 hydrochloride 10 mg/kg significantly increases wakefulness (W) (F(3,15)=3.32, P<0.05) while slow wave sleep (SWS), rapid-eye-movement sleep (REMS) and the number of REM periods are reduced (F(3,15)=4.0, P<0.01; F(3,15)=3.14, P<0.05 and F(3,15)=2.62, P<0.05, respectively). Analysis of sleep variables in 2-h blocks shows that SB-399885 hydrochloride 10 mg/kg increases W (F(3,15)=5.48, P<0.01) and reduces SWS (F(3,15)=5.42, P<0.01) and REMS (F(3,15)= 4.05, P<0.01) during the first 2-h period. SB-399885 hydrochloride 5 and 10 mg/kg augment light sleep over the first (F(3,15)=3.46,P<0.01 and F(3,15)= 3.65, P<0.01, respectively) and the second (F(3,15)=3.23, P<0.05 and F(3,15)=3.08, P<0.05, respectively) 2-h recording periods. SB-399885 hydrochloride 10 mg/kg significantly increases REMS latency (F(3,15)=3.60, P<0.01) and reduces the number of REM periods during the first 2-h of recording (F(3,15)=3.88, P<0.01)[1]. |
| Animal Admin | Twelve male Wistar rats weighing 350 to 400 g at the time of surgery are used. SB-399885 hydrochloride 2.5, 5 and 10 mg/kg or vehicle (1% aqueous solution of Tween 80) (n=6) are administered intraperitoneally in animals adapted to a 12 h dark/12 h light cycle for 4 weeks, starting 2 h after the beginning of the dark period. Each animal receives all 12 treatments. Recordings are begun 15 min later and continued for 6 h. The control solution and SB-399885 hydrochloride are given at least three days apart[1]. |
| References |
| Molecular Formula | C18H22Cl3N3O4S |
|---|---|
| Molecular Weight | 482.809 |
| Exact Mass | 481.039673 |
| Storage condition | 2-8℃ |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |