451496-96-1

451496-96-1 structure

Name: ML148
Chemical Name: [1-(3-methylphenyl)-5-benzimidazolyl]-(1-piperidinyl)methanone
CAS Number: 451496-96-1
Molecular Formula: C₂₀H₂₁N₃O
Molecular Weight: 319.40
Catalog: Signaling Pathways Metabolic Enzyme/Protease 15-PGDH
Create Date: 2018-07-01 21:12:55
Modify Date: 2024-01-02 21:40:38
ML148 is a potent and selective 15-PGDH inhibitor with an IC50 of 56 nM. ML148 has the potential for the research of prostaglandin-signaling pathways[1].

Name	[1-(3-methylphenyl)-5-benzimidazolyl]-(1-piperidinyl)methanone
Synonyms	[1-(3-Methylphenyl)-1H-benzimidazol-5-yl](1-piperidinyl)methanone Methanone, [1-(3-methylphenyl)-1H-benzimidazol-5-yl]-1-piperidinyl- [1-(3-methylphenyl)-5-benzimidazolyl]-(1-piperidinyl)methanone 1-(3-methylphenyl)-5-(piperidin-1-ylcarbonyl)-1H-benzimidazole

Description	ML148 is a potent and selective 15-PGDH inhibitor with an IC50 of 56 nM. ML148 has the potential for the research of prostaglandin-signaling pathways[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> 15-PGDH Research Areas >> Inflammation/Immunology
Target	IC50: 56 nM (15-PGDH)[1]
In Vitro	ML148 (compound 13) shows selectivity with IC50s of 56, 36000, >57500, >57500 nM for 15-PGDH, ALDH1A1, HADH2, HSD17β4, respectively[1]. ML148 (10, 20 nM) decrease Vmax by 25% and reduces the apparent Km by half at a concentration of 10 nM[1].
References	[1]. Niesen FH, et al. High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships. PLoS One. 2010 Nov 2;5(11):e13719.