1000578-26-6

1000578-26-6 structure

Name: AS 19
Chemical Name: AS-19
CAS Number: 1000578-26-6
Molecular Formula: C₁₈H₂₅N₃
Molecular Weight: 283.411
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-06-24 15:08:41
Modify Date: 2024-01-08 18:37:49
AS19 is a potent, selective 5-HT7 receptor agonist with an IC50 value of 0.83 nM and a Ki of 0.6 nM. AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis = 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively). AS19 enhances memory consolidation and reverses Scopolamine- or Dizocilpine-induced amnesia[1][2][3].

Name	AS-19
Synonyms	2-Naphthalenamine, 1,2,3,4-tetrahydro-N,N-dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-, (2S)- (2S)-N,N-Dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydro-2-naphthalenamine (2S)-N,N-Dimethyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-amine AS-19

Description	AS19 is a potent, selective 5-HT7 receptor agonist with an IC50 value of 0.83 nM and a Ki of 0.6 nM. AS19 is selective for 5-HT7 over 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT5A receptors (Kis = 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively). AS19 enhances memory consolidation and reverses Scopolamine- or Dizocilpine-induced amnesia[1][2][3].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	Human 5-HT7 Receptor:0.83 nM (IC50) Human 5-HT7 Receptor:0.6 nM (Ki) 5-HT1A Receptor:89.7 nM (Ki) 5-HT1B Receptor:490 nM (Ki) 5-HT1D Receptor:6.6 nM (Ki) 5-HT5 Receptor:98.5 nM (Ki)
In Vitro	The proliferation of T-cell from parachlorophenylalanine-treated mice is significantly reduced, addition of AS19 (1 μM) completely restores T-cell proliferation after 48 hours[2].
In Vivo	AS19 (0.5-10 mg/kg; subcutaneous injection; for 24 hours; male Wistar rats) treatment improves memory consolidation in an autoshaping Pavlovian/instrumental learning task[1]. Animal Model: Male Wistar rats (12-week-old) with autoshaping Pavlovian/instrumental learning task[1] Dosage: 0.5 mg/kg, 1 mg/kg, 5 mg/kg, 10 mg/kg Administration: Subcutaneous injection; for 24 hours Result: Enhanced memory formation in an autoshaping Pavlovian/instrumental learning task.
References	[1]. Perez-García GS, et al. Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task. Behav Brain Res. 2005 Aug 30;163(1):136-40. [2]. León-Ponte M, et al. Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor. Blood. 2007 Apr 15;109(8):3139-46. [3]. Brenchat A, et al. 5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice. Pain. 2009 Feb;141(3):239-47.

Density	1.1±0.1 g/cm3
Boiling Point	413.3±45.0 °C at 760 mmHg
Molecular Formula	C₁₈H₂₅N₃
Molecular Weight	283.411
Flash Point	203.7±28.7 °C
Exact Mass	283.204834
LogP	3.71
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.595
Storage condition	2-8°C

Hazard Codes	Xi

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