149847-77-8

149847-77-8 structure

Name: 2-MPMDQ
Chemical Name: 2-{[4-(2-Methoxyphenyl)-1-piperazinyl]methyl}-6-methyl-2,6-dihydroimidazo[1,2-c]quinazolin-5(3H)-one
CAS Number: 149847-77-8
Molecular Formula: C₂₃H₂₇N₅O₂
Molecular Weight: 405.49
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2018-06-15 19:56:44
Modify Date: 2024-03-07 13:24:44
2-MPMDQ is a potent and selective α1-adrenoceptor (Ki=0.37 nM) antagonist over α2-adrenoceptor (Ki=1740 nM). 2-MPMDQ is potent anti-hypertensive agent and has the potential for hypertension research[1].

Name	2-{[4-(2-Methoxyphenyl)-1-piperazinyl]methyl}-6-methyl-2,6-dihydroimidazo[1,2-c]quinazolin-5(3H)-one
Synonyms	Imidazo[1,2-c]quinazolin-5(3H)-one, 2,6-dihydro-2-[[4-(2-methoxyphenyl)-1-piperazinyl]methyl]-6-methyl- 2-{[4-(2-Methoxyphenyl)-1-piperazinyl]methyl}-6-methyl-2,6-dihydroimidazo[1,2-c]quinazolin-5(3H)-one 2-{[4-(2-Methoxyphenyl)piperazin-1-yl]methyl}-6-methyl-2,6-dihydroimidazo[1,2-c]quinazolin-5(3H)-one

Description	2-MPMDQ is a potent and selective α1-adrenoceptor (Ki=0.37 nM) antagonist over α2-adrenoceptor (Ki=1740 nM). 2-MPMDQ is potent anti-hypertensive agent and has the potential for hypertension research[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	α1-adrenergic receptor:0.37 nM (Ki) α2-adrenergic receptor:1740 nM (Ki)
References	[1]. J W Chern, et al. Studies on quinazolines. 5. 2,3-dihydroimidazo[1,2-c]quinazoline derivatives: a novel class of potent and selective alpha 1-adrenoceptor antagonists and antihypertensive agents. J Med Chem. 1993 Jul 23;36(15):2196-207.