1134613-19-6

1134613-19-6 structure

Name: CW 008
Chemical Name: 4-Fluoro-N-[5-fluoro-6-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]benzamide
CAS Number: 1134613-19-6
Molecular Formula: C₂₁H₁₄F₂N₆O₂
Molecular Weight: 420.372
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2018-07-10 09:05:47
Modify Date: 2024-02-03 18:39:59
CW 008, a derivative of pyrazole-pyridine, is a CREB or PKA pathway agonist. CW 008 also is a stem cell differentiating agent. CW 008 stimulates osteoblast differentiation of human MSCs and increases bone formation in ovariectomized mice. CW008 promotes osteogenesis by activating cAMP/PKA/CREB signaling pathway and inhibiting leptin secretion[1][2][3].

Name	4-Fluoro-N-[5-fluoro-6-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]benzamide
Synonyms	Benzamide, 4-fluoro-N-[5-fluoro-6-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]- 4-Fluoro-N-[5-fluoro-6-(5-methoxypyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-b]pyridin-3-yl]benzamide

Description	CW 008, a derivative of pyrazole-pyridine, is a CREB or PKA pathway agonist. CW 008 also is a stem cell differentiating agent. CW 008 stimulates osteoblast differentiation of human MSCs and increases bone formation in ovariectomized mice. CW008 promotes osteogenesis by activating cAMP/PKA/CREB signaling pathway and inhibiting leptin secretion[1][2][3].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Research Areas >> Others Signaling Pathways >> Stem Cell/Wnt >> PKA Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	PKA
References	[1]. Nooshin AMINI, et al. Methods and compositions for generating human forebrain neural progenitor cells and for maturation thereof to parvalbumin+ interneurons. Patent, WO2023075913A1. [2]. Patrick Soon-Shiong. Patient treatment via teratogenic pharmaceutical compounds. Patent, WO2016176675A2. [3]. Kim JM, et al. An activator of the cAMP/PKA/CREB pathway promotes osteogenesis from human mesenchymal stem cells. J Cell Physiol. 2013 Mar;228(3):617-26.