1191995-00-2

1191995-00-2 structure

Name: Dorzagliatin
Chemical Name: dorzagliatin
CAS Number: 1191995-00-2
Molecular Formula: C₂₂H₂₇ClN₄O₅
Molecular Weight: 462.927
Catalog: Signaling Pathways Metabolic Enzyme/Protease Glucokinase
Create Date: 2018-10-17 20:57:46
Modify Date: 2024-01-03 09:28:32
Dorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes[1].

Name	dorzagliatin
Synonyms	(2S)-2-[4-(2-Chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl]-N-{1-[(2R)-2,3-dihydroxypropyl]-1H-pyrazol-3-yl}-4-methylpentanamide X59W6980E8 1H-Pyrrole-1-acetamide, 4-(2-chlorophenoxy)-N-[1-[(2R)-2,3-dihydroxypropyl]-1H-pyrazol-3-yl]-2,5-dihydro-α-(2-methylpropyl)-2-oxo-, (αS)- dorzagliatin 10511

Description	Dorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Glucokinase Research Areas >> Metabolic Disease
Target	Glucokinase[1]
In Vivo	Dorzagliatin (low-dose 10 mg/kg, and high-dose 30 mg/kg; administered intragastrically; daily 8:00 AM for one month) exerts a glucose-lowering effect on the glucose levels in diabetic rats[2. Animal Model: Male Sprague-Dawley (SD) rats (aged approximately 6–8 weeks and weighing 200-230 g)[2 Dosage: Low-dose (10 mg/kg), and high-dose (30 mg/kg) Administration: Administered intragastrically (i.g.); daily (8:00 AM) for one month Result: Exerted a glucose-lowering effect on the glucose levels.
References	[1]. Zhu XX, et al. Dorzagliatin (HMS5552), a novel dual-acting glucokinase activator, improves glycaemic control and pancreatic β-cell function in patients with type 2 diabetes: A 28-day treatment study using biomarker-guided patient selection. Diabetes Obes Metab. 2018 Sep;20(9):2113-2120. [2]. Wang P, et al. Effects of a Novel Glucokinase Activator, HMS5552, on Glucose Metabolism in a Rat Model of Type 2 Diabetes Mellitus. J Diabetes Res. 2017;2017:5812607.