1363398-67-7

1363398-67-7 structure

Name: Isophysalin A
Chemical Name: (1S,2S,3S,5R,6S,7R,14R,15S,18S,21S)-5,7,18-Trihydroxy-1,14,21-trimethyl-25-methylene-4,20,23-trioxaheptacyclo[20.3.1.12,5.03,18.03,21.06,15.09,14]heptacosa-8,10-diene-13,19,24,27-tetrone
CAS Number: 1363398-67-7
Molecular Formula: C₂₈H₃₀O₁₀
Molecular Weight: 526.53
Catalog: Signaling Pathways Immunology/Inflammation NO Synthase
Create Date: 2018-07-20 08:09:01
Modify Date: 2025-08-25 17:18:06
Isophysalin A is a physalin with alpha and beta unsaturated ketone components. Isophysalin A binds to GSH and targets multiple cysteine residues on IKKβ. Isophysalin A also inhibits inducible NO synthase (iNOS) and nitric oxide (NO) production, showing anti-inflammatory activity[1].

Name	(1S,2S,3S,5R,6S,7R,14R,15S,18S,21S)-5,7,18-Trihydroxy-1,14,21-trimethyl-25-methylene-4,20,23-trioxaheptacyclo[20.3.1.12,5.03,18.03,21.06,15.09,14]heptacosa-8,10-diene-13,19,24,27-tetrone
Synonyms	(1S,2S,3S,5R,6S,7R,14R,15S,18S,21S)-5,7,18-Trihydroxy-1,14,21-trimethyl-25-methylene-4,20,23-trioxaheptacyclo[20.3.1.12,5.03,18.03,21.06,15.09,14]heptacosa-8,10-diene-13,19,24,27-tetrone 1,17:2,6-Dimethano-8H-naphtho[1,2-f]furo[3,4-b:2,3-c']bisoxocin-4,8,11,19(1H,10H)-tetrone, 2,3,6,6a,8a,9,10a,10b,12,16,16a,17-dodecahydro-8a,16,17-trihydroxy-2,6a,10b-trimethyl-3-methylene-, (1S,2S,6aS,8aS,10aS,10bR,16R,16aS,17R,18aS)-

Description	Isophysalin A is a physalin with alpha and beta unsaturated ketone components. Isophysalin A binds to GSH and targets multiple cysteine residues on IKKβ. Isophysalin A also inhibits inducible NO synthase (iNOS) and nitric oxide (NO) production, showing anti-inflammatory activity[1].
Related Catalog	Signaling Pathways >> NF-κB >> IKK Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Inflammation/Immunology
References	[1]. Ji L, et al. Physalins with anti-inflammatory activity are present in Physalis alkekengi var. franchetii and can function as Michael reaction acceptors. Steroids. 2012 Apr;77(5):441-7.

Hazard Codes	Xi