137348-10-8

137348-10-8 structure

Name: Osteostatin (human) trifluoroacetate salt
Chemical Name: L-Threonyl-L-arginyl-L-seryl-L-alanyl-L-tryptophyl-L-leucyl-L-α-aspartyl-L-serylglycyl-L-valyl-L-threonylglycyl-L-serylglycyl-L-leucyl-L-α-glutamylglycyl-L-α-aspartyl-L-histidyl-L-leucyl-L-seryl-L-α-aspartyl-L-threonyl-L-seryl-L-threonyl-L-threonyl-L-seryl-L-leucyl-L-α-glutamyl-L-leucyl-L-α-aspartyl-L-seryl-L-arginine
CAS Number: 137348-10-8
Molecular Formula: C₁₄₂H₂₂₈N₄₂O₅₈
Molecular Weight: 3451.576
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-06-04 02:44:29
Modify Date: 2026-06-30 12:28:43
Osteostatin (human), a fragment of parathyroid hormone-related protein (PTHrP) 107-139, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis[1].

Name	L-Threonyl-L-arginyl-L-seryl-L-alanyl-L-tryptophyl-L-leucyl-L-α-aspartyl-L-serylglycyl-L-valyl-L-threonylglycyl-L-serylglycyl-L-leucyl-L-α-glutamylglycyl-L-α-aspartyl-L-histidyl-L-leucyl-L-seryl-L-α-aspartyl-L-threonyl-L-seryl-L-threonyl-L-threonyl-L-seryl-L-leucyl-L-α-glutamyl-L-leucyl-L-α-aspartyl-L-seryl-L-arginine
Synonyms	pathyroidhormone-relatedprotein-( hypercalcemia of malignancy factor*fragment Osteostatin (huMan) HypercalceMia of Malignancy Factor (huMan), pTH-Related Protein (huMan) PTHrP HypercalceMia of Malignancy Factor (huMan), pTH-Related Protein (huMan) L-ginine, L-threonyl-L-ginyl-L-seryl-L-alanyl-L-tryptophyl-L-leucyl-L-α-asptyl-L-serylglycyl-L-valyl-L-threonylglycyl-L-serylglycyl-L-leucyl-L-α-glutamylglycyl-L-α-asptyl-L-histidyl-L-leucyl-L-seryl-L-α-asptyl-L-threonyl-L-seryl-L-threonyl-L-threonyl-L-seryl-L-leucyl-L-α-glutamyl-L-leucyl Pathyroid hormone-related protein , PTHrP , Thr-g-Ser-Ala-Trp-Leu-Asp-Ser-Gly-Val-Thr-Gly-Ser-Gly-Leu-Glu-Gly-Asp-His-Leu-Ser-Asp-Thr-Ser-Thr-Thr-Ser-Leu-Glu-Leu-Asp-Ser-g HYPERCALCEMIA OF MALIGNANCY FACTOR FRAGMENT H-THR-G-SER-ALA-TRP-LEU-ASP-SER-GLY-VAL-THR-GLY-SER-GLY-LEU-GLU-GLY-ASP-HIS-LEU-SER-ASP-THR-SER-THR-THR-SER-LEU-GLU-LEU-ASP-SER-G-OH HYPERCALCEMIA OF MALIGNANCY FACTOR (HUMAN) PTH-RELATED PROTEIN (HUMAN) L-Threonyl-L-arginyl-L-seryl-L-alanyl-L-tryptophyl-L-leucyl-L-α-aspartyl-L-serylglycyl-L-valyl-L-threonylglycyl-L-serylglycyl-L-leucyl-L-α-glutamylglycyl-L-α-aspartyl-L-histidyl-L-leucyl-L -seryl-L-α-aspartyl-L-threonyl-L-seryl-L-threonyl-L-threonyl-L-seryl-L-leucyl-L-α-glutamyl-L-leucyl-L-α-aspartyl-L-seryl-L-arginine

Description	Osteostatin (human), a fragment of parathyroid hormone-related protein (PTHrP) 107-139, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis[1].
Related Catalog	Signaling Pathways >> Others >> Thyroid Hormone Receptor Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
In Vitro	Osteostatin (100, 250 and 500 nM) 剂量依赖性的降低破骨细胞的分化，但不改变成熟破骨细胞的吸收能力。此外，Osteostatin 可降低组织蛋白酶K、破骨细胞相关IG样受体(OSCAR)和NFATc1的mRNA水平[1]。 Osteostatin可增强含Zn2+离子的介孔玻璃支架在人间充质干细胞培养中的生物活性[2]。
References	[1]. Lidia Ibáñez, et al. Osteostatin Inhibits M-CSF+RANKL-Induced Human Osteoclast Differentiation by Modulating NFATc1. Int J Mol Sci. 2022 Aug 1;23(15):8551. [2]. C Heras, et al. Osteostatin potentiates the bioactivity of mesoporous glass scaffolds containing Zn2+ ions in human mesenchymal stem cells. Acta Biomater. 2019 Apr 15;89:359-371.

Density	1.6±0.1 g/cm3
Molecular Formula	C₁₄₂H₂₂₈N₄₂O₅₈
Molecular Weight	3451.576
Exact Mass	3449.618164
LogP	-9.35
Index of Refraction	1.670

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