Osteostatin (human) trifluoroacetate salt

Modify Date: 2024-01-02 18:21:15

Osteostatin (human) trifluoroacetate salt structure	Common Name	Osteostatin (human) trifluoroacetate salt
	CAS Number	137348-10-8	Molecular Weight	3451.576
	Density	1.6±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₄₂H₂₂₈N₄₂O₅₈	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Osteostatin (human) trifluoroacetate salt

Osteostatin (human), a fragment of parathyroid hormone-related protein (PTHrP) 107-139, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis[1].

Name	L-Threonyl-L-arginyl-L-seryl-L-alanyl-L-tryptophyl-L-leucyl-L-α-aspartyl-L-serylglycyl-L-valyl-L-threonylglycyl-L-serylglycyl-L-leucyl-L-α-glutamylglycyl-L-α-aspartyl-L-histidyl-L-leucyl-L-seryl-L-α-aspartyl-L-threonyl-L-seryl-L-threonyl-L-threonyl-L-seryl-L-leucyl-L-α-glutamyl-L-leucyl-L-α-aspartyl-L-seryl-L-arginine
Synonym	More Synonyms

Description	Osteostatin (human), a fragment of parathyroid hormone-related protein (PTHrP) 107-139, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis[1].
Related Catalog	Signaling Pathways >> Others >> Thyroid Hormone Receptor Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease
In Vitro	Osteostatin (100, 250 and 500 nM) 剂量依赖性的降低破骨细胞的分化，但不改变成熟破骨细胞的吸收能力。此外，Osteostatin 可降低组织蛋白酶K、破骨细胞相关IG样受体(OSCAR)和NFATc1的mRNA水平[1]。 Osteostatin可增强含Zn2+离子的介孔玻璃支架在人间充质干细胞培养中的生物活性[2]。
References	[1]. Lidia Ibáñez, et al. Osteostatin Inhibits M-CSF+RANKL-Induced Human Osteoclast Differentiation by Modulating NFATc1. Int J Mol Sci. 2022 Aug 1;23(15):8551. [2]. C Heras, et al. Osteostatin potentiates the bioactivity of mesoporous glass scaffolds containing Zn2+ ions in human mesenchymal stem cells. Acta Biomater. 2019 Apr 15;89:359-371.

Density	1.6±0.1 g/cm3
Molecular Formula	C₁₄₂H₂₂₈N₄₂O₅₈
Molecular Weight	3451.576
Exact Mass	3449.618164
LogP	-9.35
Index of Refraction	1.670

L-Arginine, L-threonyl-L-arginyl-L-seryl-L-alanyl-L-tryptophyl-L-leucyl-L-α-aspartyl-L-serylglycyl-L-valyl-L-threonylglycyl-L-serylglycyl-L-leucyl-L-α-glutamylglycyl-L-α-aspartyl-L-histidy l-L-leucyl-L-seryl-L-α-aspartyl-L-threonyl-L-seryl-L-threonyl-L-threonyl-L-seryl-L-leucyl-L-α-glutamyl-L-leucyl-L-α-aspartyl-L-seryl-

L-Threonyl-L-arginyl-L-seryl-L-alanyl-L-tryptophyl-L-leucyl-L-α-aspartyl-L-serylglycyl-L-valyl-L-threonylglycyl-L-serylglycyl-L-leucyl-L-α-glutamylglycyl-L-α-aspartyl-L-histidyl-L-leucyl-L -seryl-L-α-aspartyl-L-threonyl-L-seryl-L-threonyl-L-threonyl-L-seryl-L-leucyl-L-α-glutamyl-L-leucyl-L-α-aspartyl-L-seryl-L-arginine

Osteostatin (human) trifluoroacetate salt

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Osteostatin (human) trifluoroacetate salt

Use of Osteostatin (human) trifluoroacetate salt

Names

Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.