Osteostatin (human) trifluoroacetate salt

Modify Date: 2025-09-25 16:13:56

Osteostatin (human) trifluoroacetate salt Structure
Osteostatin (human) trifluoroacetate salt structure
Common Name Osteostatin (human) trifluoroacetate salt
CAS Number 137348-10-8 Molecular Weight 3451.576
Density 1.6±0.1 g/cm3 Boiling Point N/A
Molecular Formula C142H228N42O58 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Osteostatin (human) trifluoroacetate salt


Osteostatin (human), a fragment of parathyroid hormone-related protein (PTHrP) 107-139, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis[1].

 Names

Name L-Threonyl-L-arginyl-L-seryl-L-alanyl-L-tryptophyl-L-leucyl-L-α-aspartyl-L-serylglycyl-L-valyl-L-threonylglycyl-L-serylglycyl-L-leucyl-L-α-glutamylglycyl-L-α-aspartyl-L-histidyl-L-leucyl-L-seryl-L-α-aspartyl-L-threonyl-L-seryl-L-threonyl-L-threonyl-L-seryl-L-leucyl-L-α-glutamyl-L-leucyl-L-α-aspartyl-L-seryl-L-arginine
Synonym More Synonyms

  Biological Activity

Description Osteostatin (human), a fragment of parathyroid hormone-related protein (PTHrP) 107-139, promotes bone repair in animal models of bone defects and prevents bone erosion in inflammatory arthritis[1].
Related Catalog
In Vitro Osteostatin (100, 250 and 500 nM) 剂量依赖性的降低破骨细胞的分化,但不改变成熟破骨细胞的吸收能力。此外,Osteostatin 可降低组织蛋白酶K、破骨细胞相关IG样受体(OSCAR)和NFATc1的mRNA水平[1]。 Osteostatin可增强含Zn2+离子的介孔玻璃支架在人间充质干细胞培养中的生物活性[2]。
References

[1]. Lidia Ibáñez, et al. Osteostatin Inhibits M-CSF+RANKL-Induced Human Osteoclast Differentiation by Modulating NFATc1. Int J Mol Sci. 2022 Aug 1;23(15):8551.  

[2]. C Heras, et al. Osteostatin potentiates the bioactivity of mesoporous glass scaffolds containing Zn2+ ions in human mesenchymal stem cells. Acta Biomater. 2019 Apr 15;89:359-371.  

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Molecular Formula C142H228N42O58
Molecular Weight 3451.576
Exact Mass 3449.618164
LogP -9.35
Index of Refraction 1.670

 Synonyms

L-Arginine, L-threonyl-L-arginyl-L-seryl-L-alanyl-L-tryptophyl-L-leucyl-L-α-aspartyl-L-serylglycyl-L-valyl-L-threonylglycyl-L-serylglycyl-L-leucyl-L-α-glutamylglycyl-L-α-aspartyl-L-histidy
 l-L-leucyl-L-seryl-L-α-aspartyl-L-threonyl-L-seryl-L-threonyl-L-threonyl-L-seryl-L-leucyl-L-α-glutamyl-L-leucyl-L-α-aspartyl-L-seryl-
L-Threonyl-L-arginyl-L-seryl-L-alanyl-L-tryptophyl-L-leucyl-L-α-aspartyl-L-serylglycyl-L-valyl-L-threonylglycyl-L-serylglycyl-L-leucyl-L-α-glutamylglycyl-L-α-aspartyl-L-histidyl-L-leucyl-L
 -seryl-L-α-aspartyl-L-threonyl-L-seryl-L-threonyl-L-threonyl-L-seryl-L-leucyl-L-α-glutamyl-L-leucyl-L-α-aspartyl-L-seryl-L-arginine
Osteostatin (human) trifluoroacetate salt
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