201939-40-4
201939-40-4 structure
- Name: PTAC oxalate
- Chemical Name: (5R,6R)-6-[4-(Propylsulfanyl)-1,2,5-thiadiazol-3-yl]-1-azabicyclo[3.2.1]octane ethanedioate (1:1)
- CAS Number: 201939-40-4
- Molecular Formula: C14H21N3O4S2
- Molecular Weight: 359.464
- Catalog: Signaling Pathways GPCR/G Protein mAChR
- Create Date: 2018-06-27 12:23:03
- Modify Date: 2024-02-09 17:52:20
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PTAC oxalate is a selective muscarinic receptor ligand. PTAC oxalate is an partial agonist of M2 and M4 but antagonist of M1, M3, and M5 (Ki values of 0.2-2.8 nM for hM1-5 in CHO cells). PTAC oxalate alleviates the mechanical allodynia on the neuropathic pain and has antidepression effects[1][2].
| Name | (5R,6R)-6-[4-(Propylsulfanyl)-1,2,5-thiadiazol-3-yl]-1-azabicyclo[3.2.1]octane ethanedioate (1:1) |
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| Synonyms |
1-Azabicyclo[3.2.1]octane, 6-[4-(propylthio)-1,2,5-thiadiazol-3-yl]-, (5R,6R)-, ethanedioate (1:1)
(5R,6R)-6-[4-(Propylsulfanyl)-1,2,5-thiadiazol-3-yl]-1-azabicyclo[3.2.1]octane ethanedioate (1:1) |
| Description | PTAC oxalate is a selective muscarinic receptor ligand. PTAC oxalate is an partial agonist of M2 and M4 but antagonist of M1, M3, and M5 (Ki values of 0.2-2.8 nM for hM1-5 in CHO cells). PTAC oxalate alleviates the mechanical allodynia on the neuropathic pain and has antidepression effects[1][2]. |
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| Related Catalog | |
| Target |
mAChR1:0.6 nM (Ki) mAChR2:2.8 nM (Ki) mAChR3:0.2 nM (Ki) mAChR4:0.2 nM (Ki) mAChR5:0.8 nM (Ki) |
| In Vivo | PTAC oxalate (0.01, 0.05 mg/kg; 腹腔给药) 在 0.05 mg/kg 时可以减轻机械异常性疼痛。PTAC oxalate 在 0.05 mg/kg 剂量下可缩短假手术组和神经损伤组小鼠的不动时间，但在 0.01 mg/kg 剂量下则不会[2]。 Animal Model: Mouse model of neuropathic pain[2] Dosage: 0.01, 0.05 mg/kg Administration: IP Result: The mechanical allodynia was alleviated with 0.05 mg/kg. At 0.05 mg/kg increased the paw withdrawal thresholds (PWTs) of the nerve-injury groups injected at day 4 after nerve injury. At 0.01 mg/kg had no effect on the PWTs in the sham and nerve-injury groups injected at day 14 after nerve injury. |
| References |
| Molecular Formula | C14H21N3O4S2 |
|---|---|
| Molecular Weight | 359.464 |
| Exact Mass | 359.097351 |