350670-85-8

350670-85-8 structure

Name: Caloxin 2A1 trifluoroacetate salt
Chemical Name: L-Valyl-L-seryl-L-asparaginyl-L-seryl-L-asparaginyl-L-tryptophyl-L-prolyl-L-seryl-L-phenylalanyl-L-prolyl-L-seryl-L-serylglycylglycylglycinamide
CAS Number: 350670-85-8
Molecular Formula: C₆₄H₉₁N₁₉O₂₂
Molecular Weight: 1478.521
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Proton Pump
Create Date: 2018-07-17 05:05:44
Modify Date: 2024-01-09 11:36:12
Caloxin 2A1 is an extracellular plasma membrane Ca2+-ATPase (PMCA) peptide inhibitor. Caloxin 2A1 does not affect basal Mg2+-ATPase or Na+-K+-ATPase[1].

Name	L-Valyl-L-seryl-L-asparaginyl-L-seryl-L-asparaginyl-L-tryptophyl-L-prolyl-L-seryl-L-phenylalanyl-L-prolyl-L-seryl-L-serylglycylglycylglycinamide
Synonyms	L-Valyl-L-seryl-L-asparaginyl-L-seryl-L-asparaginyl-L-tryptophyl-L-prolyl-L-seryl-L-phenylalanyl-L-prolyl-L-seryl-L-serylglycylglycylglycinamide Glycinamide, L-valyl-L-seryl-L-asparaginyl-L-seryl-L-asparaginyl-L-tryptophyl-L-prolyl-L-seryl-L-phenylalanyl-L-prolyl-L-seryl-L-serylglycylglycyl-

Description	Caloxin 2A1 is an extracellular plasma membrane Ca2+-ATPase (PMCA) peptide inhibitor. Caloxin 2A1 does not affect basal Mg2+-ATPase or Na+-K+-ATPase[1].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Proton Pump
In Vitro	Caloxin 2A1 inhibits Ca2+-Mg2+-ATPase in human erythrocyte leaky ghosts, but it does not affect basal Mg2+-ATPase or Na+-K+-ATPase in the ghosts or Ca2+-Mg2+-ATPase in the skeletal muscle sarcoplasmic reticulum. Caloxin 2A1 also inhibits Ca2+-dependent formation of the 140-kDa acid-stable acylphosphate[1]. Caloxin 2A1 increases airway smooth muscle cells (ASMCs) apoptosis[2].
References	[1]. J Chaudhary, et al. Caloxin: a novel plasma membrane Ca2+ pump inhibitor. Am J Physiol Cell Physiol. 2001 Apr;280(4):C1027-30. [2]. Yi-fei Chen, et al. Plasma membrane Ca2+-ATPase regulates Ca2+ signaling and the proliferation of airway smooth muscle cells. Eur J Pharmacol. 2014 Oct 5;740:733-41.