1350752-07-6

1350752-07-6 structure

Name: 5WKS
Chemical Name: 2-Chloro-N-(1-isopropyl-4-piperidinyl)-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine
CAS Number: 1350752-07-6
Molecular Formula: C₂₄H₃₆ClN₅O₂
Molecular Weight: 462.028
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2018-07-10 21:48:50
Modify Date: 2024-01-05 11:49:51
G9a-IN-1 (Compound 113) is a G9a protein inhibitor. G9A/EHMT2 is a nuclear histone lysine methyltransferase that catalyzes histone H3 lysine 9 dimethylation (H3K9me2), which is a reversible modification generally associated with transcriptional gene silencing. G9a-IN-1 can be used for the research of autoimmune disorders or cancer[1].

Name	2-Chloro-N-(1-isopropyl-4-piperidinyl)-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine
Synonyms	2-Chloro-N-(1-isopropyl-4-piperidinyl)-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine 4-Quinazolinamine, 2-chloro-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-

Description	G9a-IN-1 (Compound 113) is a G9a protein inhibitor. G9A/EHMT2 is a nuclear histone lysine methyltransferase that catalyzes histone H3 lysine 9 dimethylation (H3K9me2), which is a reversible modification generally associated with transcriptional gene silencing. G9a-IN-1 can be used for the research of autoimmune disorders or cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase Research Areas >> Inflammation/Immunology
References	[1]. Dimitrios Iliopoulos, et al. Small molecules for the treatment of autoimmune diseases and cancer. WO2022031939A1