5WKS

Modify Date: 2024-01-05 11:49:51

5WKS Structure
5WKS structure
Common Name 5WKS
CAS Number 1350752-07-6 Molecular Weight 462.028
Density 1.2±0.1 g/cm3 Boiling Point 529.3±50.0 °C at 760 mmHg
Molecular Formula C24H36ClN5O2 Melting Point N/A
MSDS N/A Flash Point 273.9±30.1 °C

 Use of 5WKS


G9a-IN-1 (Compound 113) is a G9a protein inhibitor. G9A/EHMT2 is a nuclear histone lysine methyltransferase that catalyzes histone H3 lysine 9 dimethylation (H3K9me2), which is a reversible modification generally associated with transcriptional gene silencing. G9a-IN-1 can be used for the research of autoimmune disorders or cancer[1].

 Names

Name 2-Chloro-N-(1-isopropyl-4-piperidinyl)-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine
Synonym More Synonyms

 5WKS Biological Activity

Description G9a-IN-1 (Compound 113) is a G9a protein inhibitor. G9A/EHMT2 is a nuclear histone lysine methyltransferase that catalyzes histone H3 lysine 9 dimethylation (H3K9me2), which is a reversible modification generally associated with transcriptional gene silencing. G9a-IN-1 can be used for the research of autoimmune disorders or cancer[1].
Related Catalog
References

[1]. Dimitrios Iliopoulos, et al. Small molecules for the treatment of autoimmune diseases and cancer. WO2022031939A1

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 529.3±50.0 °C at 760 mmHg
Molecular Formula C24H36ClN5O2
Molecular Weight 462.028
Flash Point 273.9±30.1 °C
Exact Mass 461.255768
LogP 4.89
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.600

 Synonyms

2-Chloro-N-(1-isopropyl-4-piperidinyl)-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine
4-Quinazolinamine, 2-chloro-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-