32350-57-5

32350-57-5 structure

Name: Stearoyl-L-carnitine chloride
Chemical Name: (2R)-3-Carboxy-N,N,N-trimethyl-2-(stearoyloxy)-1-propanaminium chloride
CAS Number: 32350-57-5
Molecular Formula: C₂₅H₅₀ClNO₄
Molecular Weight: 464.122
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GlyT
Create Date: 2018-06-07 20:01:12
Modify Date: 2024-01-11 09:58:22
Stearoyl-L-carnitine chloride is an endogenous long-chain acylcarnitine. Stearoyl-L-carnitine chloride is a less potent inhibitor of GlyT2. Stearoyl-L-carnitine chloride inhibits glycine responses by 16.8% at concentrations up 3 μM[1][2].

Name	(2R)-3-Carboxy-N,N,N-trimethyl-2-(stearoyloxy)-1-propanaminium chloride
Synonyms	1-Propanaminium, 3-carboxy-N,N,N-trimethyl-2-[(1-oxooctadecyl)oxy]-, chloride, (2R)- (1:1) (2R)-3-Carboxy-N,N,N-trimethyl-2-(stearoyloxy)-1-propanaminium chloride (2R)-3-carboxy-N,N,N-trimethyl-2-(octadecanoyloxy)propan-1-aminium chloride

Description	Stearoyl-L-carnitine chloride is an endogenous long-chain acylcarnitine. Stearoyl-L-carnitine chloride is a less potent inhibitor of GlyT2. Stearoyl-L-carnitine chloride inhibits glycine responses by 16.8% at concentrations up 3 μM[1][2].
Related Catalog	Research Areas >> Metabolic Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> GlyT Signaling Pathways >> Neuronal Signaling >> GlyT
Target	GlyT2
In Vitro	Stearoyl-L-carnitine (0.01-10 μM) inhibits glycine (30 μM) transports by 16.8% at concentrations up 3 μM in Xenopus laevis oocytes[2]. Stearoyl-L-carnitine (500 μM; 30 min) inhibits Na+-dependent [3H]carnitine (20 nM) uptake by ~50% in HPCT cells[3].
In Vivo	Stearoyl-L-carnitine is significantly decreased in Alzheimer's disease (AD), mild cognitive impairment (MCI) and subjective memory complaint (SMC)[1].
References	[1]. Cristofano A, et, al. Serum Levels of Acyl-Carnitines along the Continuum from Normal to Alzheimer's Dementia. PLoS One. 2016 May 19;11(5):e0155694. [2]. Carland JE, et, al. Oleoyl-L-carnitine inhibits glycine transport by GlyT2. Br J Pharmacol. 2013 Feb;168(4):891-902. [3]. Huang W, et, al. Carnitine transport and its inhibition by sulfonylureas in human kidney proximal tubular epithelial cells. Biochem Pharmacol. 1999 Oct 15;58(8):1361-70.

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