Stearoyl-L-carnitine chloride

Modify Date: 2025-08-20 15:37:38

Stearoyl-L-carnitine chloride Structure
Stearoyl-L-carnitine chloride structure
Common Name Stearoyl-L-carnitine chloride
CAS Number 32350-57-5 Molecular Weight 464.122
Density N/A Boiling Point N/A
Molecular Formula C25H50ClNO4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Stearoyl-L-carnitine chloride


Stearoyl-L-carnitine chloride is an endogenous long-chain acylcarnitine. Stearoyl-L-carnitine chloride is a less potent inhibitor of GlyT2. Stearoyl-L-carnitine chloride inhibits glycine responses by 16.8% at concentrations up 3 μM[1][2].

 Names

Name (2R)-3-Carboxy-N,N,N-trimethyl-2-(stearoyloxy)-1-propanaminium chloride
Synonym More Synonyms

 Stearoyl-L-carnitine chloride Biological Activity

Description Stearoyl-L-carnitine chloride is an endogenous long-chain acylcarnitine. Stearoyl-L-carnitine chloride is a less potent inhibitor of GlyT2. Stearoyl-L-carnitine chloride inhibits glycine responses by 16.8% at concentrations up 3 μM[1][2].
Related Catalog
Target

GlyT2

In Vitro Stearoyl-L-carnitine (0.01-10 μM) inhibits glycine (30 μM) transports by 16.8% at concentrations up 3 μM in Xenopus laevis oocytes[2]. Stearoyl-L-carnitine (500 μM; 30 min) inhibits Na+-dependent [3H]carnitine (20 nM) uptake by ~50% in HPCT cells[3].
In Vivo Stearoyl-L-carnitine is significantly decreased in Alzheimer's disease (AD), mild cognitive impairment (MCI) and subjective memory complaint (SMC)[1].
References

[1]. Cristofano A, et, al. Serum Levels of Acyl-Carnitines along the Continuum from Normal to Alzheimer's Dementia. PLoS One. 2016 May 19;11(5):e0155694.

[2]. Carland JE, et, al. Oleoyl-L-carnitine inhibits glycine transport by GlyT2. Br J Pharmacol. 2013 Feb;168(4):891-902.

[3]. Huang W, et, al. Carnitine transport and its inhibition by sulfonylureas in human kidney proximal tubular epithelial cells. Biochem Pharmacol. 1999 Oct 15;58(8):1361-70.

 Chemical & Physical Properties

Molecular Formula C25H50ClNO4
Molecular Weight 464.122
Exact Mass 463.342834

 Safety Information

Hazard Codes Xi

 Synonyms

1-Propanaminium, 3-carboxy-N,N,N-trimethyl-2-[(1-oxooctadecyl)oxy]-, chloride, (2R)- (1:1)
(2R)-3-Carboxy-N,N,N-trimethyl-2-(stearoyloxy)-1-propanaminium chloride
(2R)-3-carboxy-N,N,N-trimethyl-2-(octadecanoyloxy)propan-1-aminium chloride
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