Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (−)-Conophylline
Price:
Purity: 96.0%
Stocking Period: 10 Day
Contact: Yang

BioBioPha
China
Product Name: Conophylline
Price: ￥7250.0/5mg
Purity: 96.0%
Stocking Period: 10 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: (−)-Conophylline
Price: ￥9600.0/5mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: CONOPHYLLINE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

142741-24-0

142741-24-0 structure

142741-24-0 structure

Name: (−)-Conophylline
Chemical Name: Conophylline
CAS Number: 142741-24-0
Molecular Formula: C₄₄H₅₀N₄O₁₀
Molecular Weight: 794.889
Catalog: Natural product Alkaloid
Create Date: 2016-01-10 11:52:31
Modify Date: 2024-01-04 12:17:34
Conophylline is a vinca alkaloid extracted from leaves of a tropical plant Ervatamia microphylla. Conophylline is a differentiation inducer of for pancreatic cells. Conophylline suppresses HSC and induces apoptosis[1][2].

Name	Conophylline
Synonyms	2H,22H-Indolo[2'',3'':7',8']pyrrolo[1'',2'',3'':1',8']quino[2',3':4,5]furo[2,3-b]oxireno[6,7]indolizino[1,8-fg]carbazole-3,9-dicarboxylic acid, 1b,7a-diethyl-1a,1b,4,6a,7,7a,8,10,14c,15,16,17a,19,20,21a,22a-hexadecahydro-7,13-dihydroxy-11,12-dimethoxy-, dimethyl ester, (1aS,1bS,6aS,7S,7aS,14bR,14cR,17aR,18bR,21aR,22aR)- (−)-Conophylline Dimethyl (1aS,1bS,6aS,7S,7aS,14bR,14cR,17aR,18bR,21aR,22aR)-1b,7a-diethyl-7,13-dihydroxy-11,12-dimethoxy-1b,4,6a,7,7a,8,10,14c,15,16,17a,19,20,21a,22,22a-hexadecahydro-1aH,2H-indolo[2'',3'':7',8']pyrrolo[1'',2'',3'':1',8']quinolino[2',3':4,5]furo[2,3-b]oxireno[6,7]indolizino[1,8-fg]carbazole-3,9-dicarboxylate

Description	Conophylline is a vinca alkaloid extracted from leaves of a tropical plant Ervatamia microphylla. Conophylline is a differentiation inducer of for pancreatic cells. Conophylline suppresses HSC and induces apoptosis[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Endocrinology Research Areas >> Neurological Disease
In Vitro	Conophylline (100 ng/ml; 48 hours) reproduces differentiationinducing activity but not apoptosis-inducing activity of activin[1]. Conophylline (100 ng/ml; 72 hours) exhibits the differentiation-inducing activity in AR42J cells and converts these cells to endocrine cells[1]. Conophylline increases the expression of neurogenin-3 by activating p38 mitogen-activated protein kinase to induce differentiation of AR42J cells[1]. Conophylline reduces the expression of α-SMA and collagen-1 in rat HSC and Lx-2 cells[2]. Conophylline inhibits DNA synthesis induced by serum[2]. Conophylline also promots activation of caspase-3 and induces apoptosis in Lx-2 Cells[2]. Apoptosis Analysis[2] Cell Line: Lx-2 Cells Concentration: 12 hours Incubation Time: 0.1 μg/ml Result: Induced apoptosis Western Blot Analysis[2] Cell Line: Lx-2 cells Concentration: 0.1 μg/ml Incubation Time: 15 minutes, 30 minutes, 60 minutes, 120 minutes Result: Increased phospho-JNK.
In Vivo	Conophylline (0.9 mg/kg; p.o.; daily; for 12 weeks) attenuates formation of the liver fibrosis induced by TAA in vivo[2]. Animal Model: Sprague-Dawley rats (70-80 g)[2] Dosage: 0.9 mg/kg Administration: Oral administration; daily; for 12 weeks Result: Attenuated formation of the liver fibrosis induced by TAA.
References	[1]. Kojima I, et al. Conophylline: a novel differentiation inducer for pancreatic beta cells. Int J Biochem Cell Biol. 2006;38(5-6):923-30. [2]. Kubo N, et al. Conophylline suppresses hepatic stellate cells and attenuates thioacetamide-induced liver fibrosis in rats. Liver Int. 2014 Aug;34(7):1057-67.

Density	1.5±0.1 g/cm3
Molecular Formula	C₄₄H₅₀N₄O₁₀
Molecular Weight	794.889
Exact Mass	794.352722
PSA	163.82000
LogP	4.49
Index of Refraction	1.728