Top Suppliers:I want be here


  • DC Chemicals Limited
  • China
  • Product Name: GSK'843
  • Price: ¥800.0/100mg ¥1450.0/250mg ¥2900.0/1g
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Tony Cao

1601496-05-2

1601496-05-2 structure
1601496-05-2 structure
  • Name: GSK-843
  • Chemical Name: 3-(1,3-Benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine
  • CAS Number: 1601496-05-2
  • Molecular Formula: C19H15N5S2
  • Molecular Weight: 377.49
  • Catalog: Signaling Pathways Apoptosis RIP kinase
  • Create Date: 2018-06-23 00:29:48
  • Modify Date: 2024-01-22 22:56:48
  • GSK-843 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM[1].

Name 3-(1,3-Benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine
Synonyms 3-(1,3-Benzothiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine
Thieno[3,2-c]pyridin-4-amine, 3-(5-benzothiazolyl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)-
Description GSK-843 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM[1].
Related Catalog
Target

IC50: 6.5 nM (RIP3)[1]

References

[1]. Mandal P, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20;56(4):481-95.

Density 1.5±0.1 g/cm3
Boiling Point 640.0±55.0 °C at 760 mmHg
Molecular Formula C19H15N5S2
Molecular Weight 377.49
Flash Point 340.8±31.5 °C
Exact Mass 377.076874
LogP 4.90
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.832
Hazard Codes Xi