154355-75-6
154355-75-6 structure
- Name: COX/5-LO-IN-1
- Chemical Name: Atreleuton
- CAS Number: 154355-75-6
- Molecular Formula: C16H15FN2O2S
- Molecular Weight: 318.371
- Catalog: Signaling Pathways Metabolic Enzyme/Protease 5-Lipoxygenase
- Create Date: 2018-07-13 16:09:45
- Modify Date: 2024-01-11 05:35:07
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COX/5-LO-IN-1 is an inhibitor of cylooxygenase and 5-lipoxygenase, used for the research of inflammatory and allergic disease states.
| Name | Atreleuton |
|---|---|
| Synonyms | COX/5-LO-IN-1 |
| Description | COX/5-LO-IN-1 is an inhibitor of cylooxygenase and 5-lipoxygenase, used for the research of inflammatory and allergic disease states. |
|---|---|
| Related Catalog | |
| Target |
5-Lipoxygenase:2 μM (IC50) COX |
| In Vitro | COX/5-LO-IN-1 reduces the biosynthesis of leukotrienes B4, C4, D4, and E4 and cyclooxygenase products such as prostaglandins and thromboxane and are useful in the treatment of inflammatory and allergic disease states[1]. COX/5-LO-IN-1 shows inhibitory activities against 5-lipoxygenase, with IC50 of 0.2 μM in human whole blood[2]. |
| References |
[1]. Lipoxygenase and cyclooxygenase inhibiting compounds. US 5516789 A |
| Molecular Formula | C16H15FN2O2S |
|---|---|
| Molecular Weight | 318.371 |