COX/5-LO-IN-1

Modify Date: 2024-01-11 05:35:07

Use of COX/5-LO-IN-1

COX/5-LO-IN-1 is an inhibitor of cylooxygenase and 5-lipoxygenase, used for the research of inflammatory and allergic disease states.

Name	Atreleuton
Synonym	More Synonyms

Description	COX/5-LO-IN-1 is an inhibitor of cylooxygenase and 5-lipoxygenase, used for the research of inflammatory and allergic disease states.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase Research Areas >> Inflammation/Immunology
Target	5-Lipoxygenase:2 μM (IC50) COX
In Vitro	COX/5-LO-IN-1 reduces the biosynthesis of leukotrienes B4, C4, D4, and E4 and cyclooxygenase products such as prostaglandins and thromboxane and are useful in the treatment of inflammatory and allergic disease states[1]. COX/5-LO-IN-1 shows inhibitory activities against 5-lipoxygenase, with IC50 of 0.2 μM in human whole blood[2].
References	[1]. Lipoxygenase and cyclooxygenase inhibiting compounds. US 5516789 A [2]. Brooks CD, et al. (R)-(+)-N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl- 2-propynyl]-N-hydroxyurea (ABT-761), a second-generation 5-lipoxygenase inhibitor. J Med Chem. 1995 Nov 24;38(24):4768-75.

Molecular Formula	C₁₆H₁₅FN₂O₂S
Molecular Weight	318.371

COX/5-LO-IN-1

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Price: ￥11400/1 mg

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