- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Jolkinolide A
- Price: Check
- Purity: 95.0%
- Stocking Period: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- BioBioPha
- China
- Product Name: Jolkinolide A
- Price: ￥4250.0/5mg
- Purity: 97.0%
- Stocking Period: 10 Day
- Contact: Xueping-Zheng
- Email: 1477035482@qq.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Jolkinolide A
- Price: ￥5760.0/5mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- DC Chemicals Limited
- China
- Product Name: Jolkinolide A
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: jolkinolide A
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
37905-07-0
37905-07-0 structure
- Name: Jolkinolide A
- Chemical Name: jolkinolide A
- CAS Number: 37905-07-0
- Molecular Formula: C20H26O3
- Molecular Weight: 314.41864
- Catalog: Natural product Moss
- Create Date: 2019-01-20 07:16:40
- Modify Date: 2025-08-23 12:06:49
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Jolkinolide A is a diterpenoid, can be extracted from the roots of Euphorbia fischeriana Steud. Jolkinolide A exhibits anti-tumor activity, by affecting on angiogenesis of tumor tissues. Jolkinolide A significantly inhibits the Akt-STAT3-mTOR signaling pathway and reduces the expression of VEGF in A549 cells[1].
| Name | jolkinolide A |
|---|---|
| Synonyms |
2H-Oxireno[1,10a]phenanthro[3,2-b]furan-10(11bH)-one, 3,3a,4,5,6,7,7a,7b-octahydro-4,4,7a,11-tetramethyl-, (1aS,3aR,7aR,7bS,11bR)-
(5β,9β,10α,14β)-8,14:12,16-Diepoxyabieta-11,13(15)-dien-16-one Jolkinolide A |
| Description | Jolkinolide A is a diterpenoid, can be extracted from the roots of Euphorbia fischeriana Steud. Jolkinolide A exhibits anti-tumor activity, by affecting on angiogenesis of tumor tissues. Jolkinolide A significantly inhibits the Akt-STAT3-mTOR signaling pathway and reduces the expression of VEGF in A549 cells[1]. |
|---|---|
| Related Catalog | |
| Target |
VEGF[1] |
| In Vitro | Jolkinolide A (20-100 μg/mL; 24 h) 提高 A549 细胞中 caspase-9 蛋白水平[1]。 Jolkinolide A (40-80 μg/mL; 24 h) 降低 A549 细胞中 Akt-STAT3-mTOR 蛋白的表达[1]。 Jolkinolide A (20-100 μg/mL; 24 h) 抑制人脐静脉内皮细胞 (HUVEC) 增殖和迁移，促进细胞凋亡[1]。 Western Blot Analysis[1] Cell Line: A549 cells Concentration: 20 μg/mL, 40 μg/mL, 60 μg/mL, 80 μg/mL, and 100 μg/mL Incubation Time: 24 hours Result: Promoted caspase-9 protein expression in cells at 20-100 μg/mL.Inhibited expression levels of Akt, STAT3, and mTOR proteins in cells at 40-80 μg/mL. |
| In Vivo | Jolkinolide A (40 mg/kg; 腹腔注射; 每 3 天一次，持续 2 个月) 抑制小鼠A549细胞异种移植瘤模型中VEGF蛋白的表达[1]。 Animal Model: Female BALB/c nude mice (4-5 weeks old) injected with A549 cells[1] Dosage: 40 mg/kg Administration: Intraperitoneal injection; once every 3 days for 2 months Result: Significantly inhibited the expression of VEGF protein on the first, 10th, 30th, 45th, and 60th day of administration. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 479.5±45.0 °C at 760 mmHg |
| Molecular Formula | C20H26O3 |
| Molecular Weight | 314.41864 |
| Flash Point | 206.7±23.3 °C |
| Exact Mass | 314.188202 |
| LogP | 4.70 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.579 |
| Storage condition | 2-8℃ |
| Hazard Codes | Xi |
|---|