1202710-57-3

1202710-57-3 structure

Name: GSTO-IN-2
Chemical Name: GSTO-IN-2
CAS Number: 1202710-57-3
Molecular Formula: C₃₃H₅₂N₂O₉
Molecular Weight: 620.77
Catalog: Signaling Pathways Metabolic Enzyme/Protease Gutathione S-transferase
Create Date: 2018-09-30 02:01:38
Modify Date: 2024-01-14 08:07:09
GSTO-IN-2 is a glutathione S-transferase inhibitor with IC50s of 3.6, 16.3, and 1.4 μM for GSTA2, GSTM1, and GSTP1-1.

Name	GSTO-IN-2

Description	GSTO-IN-2 is a glutathione S-transferase inhibitor with IC50s of 3.6, 16.3, and 1.4 μM for GSTA2, GSTM1, and GSTP1-1.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Gutathione S-transferase Research Areas >> Cancer
Target	IC50: 3.6 μM (GSTA2), 16.3 μM (GSTM1), 1.4 μM (GSTP1-1)[1]
In Vitro	GSTO-IN-2 is compound 3 in the reference. GSTO-IN-2 shows synergetic effect with chemotherapy drugs against two breast cancer cell lines through the inactivation of GST isozymes. The maximal enhancement of cisplatin-induced inhibition of cell viability is observed at 50 μM GSTO-IN-2, up to 640% against MCF-7 and up to 270% against MDA-MB-231. Viability inhibition of thiotepa is enhanced by GSTO-IN-2 (25 and 50 μM), up to 170-320% against MCF-7 and up to 180-270% against MDA-MB-231.[1].
References	[1]. Chang KH, et al. Lithocholic acid analogues, new and potent alpha-2,3-sialyltransferase inhibitors. Chem Commun (Camb). 2006 Feb 14;(6):629-31.