GSTO-IN-2 structure
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Common Name | GSTO-IN-2 | ||
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CAS Number | 1202710-57-3 | Molecular Weight | 620.77 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C33H52N2O9 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of GSTO-IN-2GSTO-IN-2 is a glutathione S-transferase inhibitor with IC50s of 3.6, 16.3, and 1.4 μM for GSTA2, GSTM1, and GSTP1-1. |
Name | GSTO-IN-2 |
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Description | GSTO-IN-2 is a glutathione S-transferase inhibitor with IC50s of 3.6, 16.3, and 1.4 μM for GSTA2, GSTM1, and GSTP1-1. |
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Related Catalog | |
Target |
IC50: 3.6 μM (GSTA2), 16.3 μM (GSTM1), 1.4 μM (GSTP1-1)[1] |
In Vitro | GSTO-IN-2 is compound 3 in the reference. GSTO-IN-2 shows synergetic effect with chemotherapy drugs against two breast cancer cell lines through the inactivation of GST isozymes. The maximal enhancement of cisplatin-induced inhibition of cell viability is observed at 50 μM GSTO-IN-2, up to 640% against MCF-7 and up to 270% against MDA-MB-231. Viability inhibition of thiotepa is enhanced by GSTO-IN-2 (25 and 50 μM), up to 170-320% against MCF-7 and up to 180-270% against MDA-MB-231.[1]. |
References |
Molecular Formula | C33H52N2O9 |
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Molecular Weight | 620.77 |
Storage condition | 2-8℃ |