108237-91-8

108237-91-8 structure

Name: RCGD 423
Chemical Name: RCGD423
CAS Number: 108237-91-8
Molecular Formula: C₁₅H₁₁BrN₂S
Molecular Weight: 331.230
Catalog: Signaling Pathways Immunology/Inflammation Interleukin Related
Create Date: 2019-01-20 11:35:52
Modify Date: 2025-08-25 18:19:00
RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair.

Name	RCGD423
Synonyms	2-Thiazolamine, N-(4-bromophenyl)-4-phenyl- N-(4-Bromophenyl)-4-phenyl-1,3-thiazol-2-amine

Description	RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair.
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	gp130[1]
In Vitro	RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair[1].
In Vivo	RCGD423 greatly reduces chondrocyte hypertrophy, loss and degeneration while increasing chondrocyte proliferation beyond that observed in response to injury in a rat partial meniscectomy model. Moreover, RCGD 423 improves cartilage healing in a rat full-thickness osteochondral defect model, increasing proliferation of mesenchymal cells in the defect and also inhibiting breakdown of cartilage matrix in de novo generated cartilage[1].
References	[1]. Shkhyan R, et al. Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair. Ann Rheum Dis. 2018 May;77(5):760-769.