675103-36-3
675103-36-3 structure
- Name: BAY 678
- Chemical Name: BAY-678
- CAS Number: 675103-36-3
- Molecular Formula: C20H15F3N4O2
- Molecular Weight: 400.35
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Elastase
- Create Date: 2019-02-08 19:56:19
- Modify Date: 2024-04-05 18:51:44
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BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).
| Name | BAY-678 |
|---|
| Description | BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC). |
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| Related Catalog | |
| Target |
IC50: 20 nM (HNE)[1]. |
| In Vitro | BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. The Ki value of BAY-678 for MNE is 700 nM. BAY-678 is the 4 th generation inhibitor of HNE[1]. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC)[2]. |
| In Vivo | BAY-678 (17) reveals significant efficacy in preclinical models of ALI and lung emphysema, demonstrating their anti-inflammatory and anti-remodeling mode of action. Additionally, BAY-678 (17) has shown significant beneficial pulmonary hemodynamic and vascular effects in models of PAH in rats and mice[2]. |
| References |
| Molecular Formula | C20H15F3N4O2 |
|---|---|
| Molecular Weight | 400.35 |
| Storage condition | 2-8℃ |