1638526-21-2

1638526-21-2 structure

Name: EMT inhibitor-1
Chemical Name: EMT inhibitor-1
CAS Number: 1638526-21-2
Molecular Formula: C₁₂H₁₂Cl₂N₂O₂S
Molecular Weight: 319.21
Catalog: Signaling Pathways Stem Cell/Wnt Hippo (MST)
Create Date: 2019-02-09 11:35:07
Modify Date: 2024-01-02 21:46:04
EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.

Name	EMT inhibitor-1

Description	EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Hippo (MST) Signaling Pathways >> Stem Cell/Wnt >> TGF-beta/Smad Signaling Pathways >> TGF-beta/Smad >> TGF-beta/Smad Signaling Pathways >> Stem Cell/Wnt >> Wnt Research Areas >> Cancer
Target	Hippo, TGF-β, Wnt[1].
In Vitro	EMT inhibitor-1 (C19) is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities, inhibiting cancer cell migration, proliferation, and resistance to doxorubicin in vitro[1].
In Vivo	EMT inhibitor-1 (C19) exerts strong antitumor activity in a mouse tumor model. Mechanistically, EMT inhibitor-1 induces GSK3-β–mediated degradation of the Hippo transducer TAZ, through activation of the Hippo kinases Mst/Lats and the tumor suppressor kinase AMPK upstream of the degradation complex[1].
References	[1]. Basu D, et al. Identification, mechanism of action, and antitumor activity of a small molecule inhibitor of hippo, TGF-β, and Wnt signaling pathways. Mol Cancer Ther. 2014 Jun;13(6):1457-67.