EMT inhibitor-1
Modify Date: 2024-01-02 21:46:04
EMT inhibitor-1 structure
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Common Name | EMT inhibitor-1 | ||
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| CAS Number | 1638526-21-2 | Molecular Weight | 319.21 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C12H12Cl2N2O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of EMT inhibitor-1EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities. |
| Name | EMT inhibitor-1 |
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| Description | EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities. |
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| Related Catalog | |
| Target |
Hippo, TGF-β, Wnt[1]. |
| In Vitro | EMT inhibitor-1 (C19) is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities, inhibiting cancer cell migration, proliferation, and resistance to doxorubicin in vitro[1]. |
| In Vivo | EMT inhibitor-1 (C19) exerts strong antitumor activity in a mouse tumor model. Mechanistically, EMT inhibitor-1 induces GSK3-β–mediated degradation of the Hippo transducer TAZ, through activation of the Hippo kinases Mst/Lats and the tumor suppressor kinase AMPK upstream of the degradation complex[1]. |
| References |
| Molecular Formula | C12H12Cl2N2O2S |
|---|---|
| Molecular Weight | 319.21 |
| Storage condition | 2-8℃ |