1919888-06-4

1919888-06-4 structure

Name: LY3295668 (AK-01)
Chemical Name: LY3295668
CAS Number: 1919888-06-4
Molecular Formula: C₂₄H₂₆ClF₂N₅O₂
Molecular Weight: 489.95
Catalog: Signaling Pathways Cell Cycle/DNA Damage Aurora Kinase
Create Date: 2019-02-16 18:36:01
Modify Date: 2025-09-22 23:00:48
LY3295668 is a potent, orally active and highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively.

Name	LY3295668

Description	LY3295668 is a potent, orally active and highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase Signaling Pathways >> Epigenetics >> Aurora Kinase Research Areas >> Cancer
Target	Aurora A:0.8 nM (IC50)
In Vitro	LY3295668 is a highly specific Aurora-A kinase inhibitor, with Ki values of 0.8 nM and 1038 nM for AurA and AurB, respectively. LY3295668, a highly specific AurA inhibitor, can kill Rb-deficient cancer cells at doses that have minimal effects on normal cells. In a kinome-wide survey, only 5 of 386 kinases are potently inhibited by LY3295668 (<10 nM)[1].
References	[1]. Gong X, et al. Aurora-A kinase inhibition is synthetic lethal with loss of the RB1 tumor suppressor gene. Cancer Discov. 2018 Oct 29. pii: CD-18-0469.