2227019-45-4
2227019-45-4 structure
- Name: Aurora inhibitor 1
- Chemical Name: Aurora inhibitor 1
- CAS Number: 2227019-45-4
- Molecular Formula: C23H25N9S
- Molecular Weight: 459.57
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Aurora Kinase
- Create Date: 2019-03-03 11:39:12
- Modify Date: 2024-01-04 15:04:20
-
Aurora inhibitor 1 is a potent Aurora inhibitor with an IC50 of ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase, respectively[1].
| Name | Aurora inhibitor 1 |
|---|
| Description | Aurora inhibitor 1 is a potent Aurora inhibitor with an IC50 of ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
Aurora A:4 nM (IC50) Aurora B:13 nM (IC50) |
| In Vitro | Aurora inhibitor 1 (Compound 16) exhibits Kd values of 0.01 nM for both Aurora A and Aurora B kinase[1]. |
| In Vivo | Aurora inhibitor 1 (Compound 16) exhibits good drug exposure levels across species upon oral dosing, and shows excellent in vivo efficacy in a mouse xenograft tumor model when dosed orally[1]. |
| References |
| Molecular Formula | C23H25N9S |
|---|---|
| Molecular Weight | 459.57 |
| Hazard Codes | Xi |
|---|