DC Chemicals Limited
China
Product Name: Aurora inhibitor 1
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

2227019-45-4

2227019-45-4 structure

2227019-45-4 structure

Name: Aurora inhibitor 1
Chemical Name: Aurora inhibitor 1
CAS Number: 2227019-45-4
Molecular Formula: C₂₃H₂₅N₉S
Molecular Weight: 459.57
Catalog: Signaling Pathways Cell Cycle/DNA Damage Aurora Kinase
Create Date: 2019-03-03 11:39:12
Modify Date: 2024-01-04 15:04:20
Aurora inhibitor 1 is a potent Aurora inhibitor with an IC50 of ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase, respectively[1].

Name	Aurora inhibitor 1

Description	Aurora inhibitor 1 is a potent Aurora inhibitor with an IC50 of ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase, respectively[1].
Related Catalog	Signaling Pathways >> Epigenetics >> Aurora Kinase Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase
Target	Aurora A:4 nM (IC50) Aurora B:13 nM (IC50)
In Vitro	Aurora inhibitor 1 (Compound 16) exhibits Kd values of 0.01 nM for both Aurora A and Aurora B kinase[1].
In Vivo	Aurora inhibitor 1 (Compound 16) exhibits good drug exposure levels across species upon oral dosing, and shows excellent in vivo efficacy in a mouse xenograft tumor model when dosed orally[1].
References	[1]. Yu T, et al. Discovery of a highly potent orally bioavailable imidazo-[1, 2-a]pyrazine Aurora inhibitor. Bioorg Med Chem Lett. 2018 May 1;28(8):1397-1403.

Molecular Formula	C₂₃H₂₅N₉S
Molecular Weight	459.57

Hazard Codes	Xi