2140301-96-6

2140301-96-6 structure

Name: PF-06700841 P-Tosylate
Chemical Name: PF-06700841 P-Tosylate
CAS Number: 2140301-96-6
Molecular Formula: C₂₅H₂₉F₂N₇O₄S
Molecular Weight: 561.60
Catalog: Signaling Pathways Epigenetics JAK
Create Date: 2019-03-30 22:47:34
Modify Date: 2024-01-16 20:31:33
PF-06700841 P-Tosylate is a dual JAK1 and TYK2 inhibitor with IC50s of 17 and 23 nM, respectively. Anti-inflammatory activity[1].

Name	PF-06700841 P-Tosylate

Description	PF-06700841 P-Tosylate is a dual JAK1 and TYK2 inhibitor with IC50s of 17 and 23 nM, respectively. Anti-inflammatory activity[1].
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
Target	IC50: 17 nM (JAK1), 23 nM (TYK2)[1]
References	[1]. Fensome A, et al. Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841). J Med Chem. 2018 Oct 11;61(19):8597-8612.