1628502-91-9
1628502-91-9 structure
- Name: MW-150
- Chemical Name: MW-150
- CAS Number: 1628502-91-9
- Molecular Formula: C24H23N5
- Molecular Weight: 381.47
- Catalog: Signaling Pathways MAPK/ERK Pathway p38 MAPK
- Create Date: 2019-06-03 12:16:23
- Modify Date: 2024-01-10 17:59:50
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MW150 (MW01-18-150SRM) is a selective inhibitor of p38αMAPK isoform with a ki of 101 nM[1].
| Name | MW-150 |
|---|
| Description | MW150 (MW01-18-150SRM) is a selective inhibitor of p38αMAPK isoform with a ki of 101 nM[1]. |
|---|---|
| Related Catalog | |
| Target |
p38α:101 nM (Ki) |
| In Vitro | MW150 inhibits in a concentration-dependent manner the ability of the endogenous p38αMAPK to phosphorylate an endogenous substrate MK2 in activated glia[1]. MW150 blocks in a concentration-dependent manner the increased IL-1β production by activated glia. The IC50 values are 332 nM and 936 nM for MK2 and IL-1β, respectively[1]. |
| In Vivo | MW150 (2.5 mg/kg; oral daily for 3-4 months) improves the APP/PS1 transgenic (Tg) mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests[1]. MW150 (2.5 mg/kg; given i.p.; daily for 14 days) treatment in APPNLh/NLh × PSP264L/P264L knock-in mouse (with no overexpression of the amyloid precursor protein) exhibits RAWM behavior indistinguishable from WT mice[1]. Animal Model: APP/PS1 transgenic (Tg) mouse (overexpresses amyloid-beta)[1] Dosage: 2.5 mg/kg Administration: Oral daily; 3-4 months (until cognitive impairment is present) Result: Improved the Tg mice performance in radial arm water maze (RAWM) and contextual fear conditioning tests. |
| References |
| Molecular Formula | C24H23N5 |
|---|---|
| Molecular Weight | 381.47 |